Clinical Trial

Investigating the Impact of Nudging Cardiologists to Prescribe Guideline-directed Medical Therapy in Heart Failure Patients

Study acronym: ADMINISTER II
Enrolling by Invitation
View on ClinicalTrials.gov →
Summary
This study investigates the impact of a nudge-based intervention on improving guideline directed medical therapy (GDMT) prescription among cardiologists. Using a stepped wedge randomized controlled trial design, we assess whether digital decision support-leveraging home monitoring and clinical data-enhances adherence to guideline-recommended medication titration. The primary outcomes include HF related hospitalization rates and all cause mortality.
Protocol Amendment History 3 changes
critical Trial status changed: Recruiting → Enrolling by Invitation 2026-08-11
notable Trial sites expanded: 1 -> 5 locations 2026-08-11
notable Primary completion pushed: 2027-04-30 -> 2028-03-30 2026-08-11
Trial Details
NCT Number NCT06844006
Lead Sponsor Medisch Spectrum Twente
Collaborators: Onze Lieve Vrouwe Gasthuis, St. Antonius Hospital, Catharina Ziekenhuis Eindhoven, Maasstad Hospital, Rotterdam
Conditions Heart Failure
Enrollment 1,320 participants
Start Date 2024-06-13
Primary Completion 2028-03-30 (estimated)
Study Completion 2028-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-10