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Association Between GalectiN-3 and pOSt-operative atrIal Fibrillation After Coronary Artery bypaSs Graft

Study acronym: GNOSIS
StatusActive, Not Recruiting
PhaseNot specified
Started2023-01-01
View on ClinicalTrials.gov ↗

Amendment history

2026-09-08
notable
Study Identification, Study Status, Oversight, Outcome Measures, Contacts/Locations v1
Enrollment closed, study ongoing
Primary completion 2026-01-27, at least 333 days after the final estimate of 2025-02-28
Primary completion dateestimated 2025-02-28→confirmed 2026-01-27
Completion date2026-12-01→2026-12
Secondary endpointsdetails revised at 1 of 3 entries
Study sitesdetails revised at 1 of 1 site
Study titlerevised
Association Between GalectiN-3 and POStpOSt-operative AtrIalatrIal Fibrillation After Coronary Artery BypaSsbypaSs Graft
2025-01-06
minor
Original filing
The goal of this observational study is to test the association between high levels of Galectin-3 and the occurrence of post-operative atrial fibrillation after isolated coronary artery bypass grafting (CABG). The main question\[s\] it aims to answer are: * Is Galectin-3 an accurate biomarker to predict higher risk of developing post-operative atrial fibrillation? * Are high levels of Galectin-3 associated to other post-operative complications and major adverse cardiovascular events? Participants will be enrolled during pre-operative evaluation and a peripheral blood sample collection will be performed in the 24h before CABG. Participants will then be followed for a period of 12 months (daily during hospitalization and 3 appointments after hospital discharge) to determine whether patients with higher levels of Galectin-3 will have worse outcomes.
Trial Details
NCT Number NCT06768528
Lead Sponsor University of Sao Paulo General Hospital
Conditions Post-operative Atrial Fibrillation, Cardiovascular Diseases, Post-pericardiotomy Syndrome
Enrollment 90 participants
Start Date 2023-01-01
Primary Completion 2026-01-27 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-09-11