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NCT06733922 · ClinicalTrials.gov record · last posted 2026-05-15

ELIOS - Investigational Biomarkers to Track Disease Modification in Active RRMS

Study acronym: ELIOS
StatusRecruiting
PhasePhase 4
Started2024-11-27
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
The exploratory ELIOS study aims to assess the value of novel investigational Eye Movement Biomarkers (EMBs) in tracking disease-related changes among a real-world cohort of Canadian patients with active RRMS, within the context of disease-modifying treatment (i.e., ofatumumab). To that end, the study will use the patented investigational, Eye Tracking Neurological Assessment (ETNA-ProgMS) SaMD (v1.0.11 or later), which has not yet received Health Canada approval, to reliably and accurately track eye movements with precision.

Protocol amendment history 2 changes detected by DataLookout

2026-05-16
critical
Primary completion pushed: 2027-11-30 → 2028-11-30
2026-05-16
minor
Completion pushed: 2027-11-30 → 2028-11-30
Trial Details
NCT Number NCT06733922
Lead Sponsor Novartis Pharmaceuticals
Conditions Relapsing Remitting Multiple Sclerosis (RRMS)
Enrollment 224 participants
Start Date 2024-11-27
Primary Completion 2028-11-30 (estimated)
Study Completion 2028-11-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-15