Clinical Trial

Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA

Study acronym: MY-FUSION
Recruiting
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Record status
This record was last updated April 25, 2025 (before its estimated August 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, the investigators aim to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and utilizing myocardial flow reserve calculated from dynamic SPECT images. 50 patients with suspected coronary artery disease are anticipated to be enrolled. Pharmacological stress and rest-phase dynamic and static MPI SPECT following an additional coronary CTA scan are to be performed. The obtained multimodality imaging data (functional and anatomical parameters) are planned to be compared and subjected to statistical analysis. The results of this study are expected to improve risk assessment for patients with moderate cardiovascular risk and enhance the diagnostic performance of MPI SPECT.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-10-31.
Trial Details
NCT Number NCT06670768
Lead Sponsor Semmelweis University
Conditions Coronary Artery Disease, Coronary Computed Tomography Angiography, SPECT, Heart Diseases, Cardiovascular Diseases, Arteriosclerosis, Myocardial Ischemia, Coronary Disease +1 more
Enrollment 50 participants
Start Date 2024-03-06
Primary Completion 2025-08-30 (estimated)
Study Completion 2026-08-30 (estimated)
Updated on ClinicalTrials.gov 2025-04-25