Clinical Trial

The Influence of Modifying Highly Calcified Coronary Lesions on Coronary Microcirculation

Enrolling by Invitation

Record status

This record was last updated November 24, 2025 (before its estimated June 2026 completion). Its status may not reflect the trial's current state.

Summary

This is a prospective, single-center, three-arm study to evaluate the impact of severely calcified coronary lesions treatment on microvascular circulation. We will enroll 30 conveniently sampled subjects assigned to one of three therapeutical methods lithotripsy, super-high pressure balloon, and orbital atherectomy prior to implantation of drug-eluting stents (DES).

Protocol Amendment History 1 amendment

This ClinicalTrials.gov record has been amended once since 2024-07-12.

Trial Details

NCT Number	NCT06507449
Lead Sponsor	Medical University of Silesia Collaborators: Polish Cardiac Society
Conditions	Coronary Artery Calcification, Ischemic Heart Disease, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), Coronary Artery Disease, Angina, Unstable, Tomography, Optical Coherence
Enrollment	30 participants
Start Date	2024-03-07
Primary Completion	2026-06 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2025-11-24