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Inflammation and Postoperative Atrial Fibrillation in Cardiac Surgery

StatusCompleted
PhaseNot specified
Started
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Record History

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  1. Trial completed Show 5 more changesShow less
    • Final enrollment: 85 participants (planned 100)
    • Primary completion date changed from estimate of Jan 1, 2027 to Jan 1, 2026
    • Site details revised
    • Publications: details revised at 3 of 3 entries
    • Eligibility criteria expanded, about 5 words
  2. Primary and study completion dates: Jan 1, 2025 to Jan 1, 2027v3
  3. Primary endpoint revised
    • Study description revised
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery, marked by an irregular and rapid heart rate, and associated with increased morbidity, longer hospital stays, and higher costs. Its complex pathophysiology involves atrial remodeling, inflammation, and autonomic dysregulation. Surgical trauma and cardiopulmonary bypass trigger an inflammatory response, releasing cytokines. Epicardial fat around the heart secretes pro-inflammatory cytokines, and its increased thickness is linked to higher inflammation and atrial fibrillation. This study uses RNA sequencing (RNA-seq) to profile gene expression in epicardial fat, identifying key genes involved in inflammation and metabolism. By comparing patients with and without POAF, RNA-seq reveals differentially expressed genes associated with postoperative atrial fibrillation.
Trial Details
NCT Number NCT06475547
Lead Sponsor Odense University Hospital
Conditions
(from sponsor)		 Atrial Fibrillation, Inflammation
Related terms Atrial Fibrillation, Inflammation
Enrollment 85 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov