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Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study

StatusRecruiting
PhaseNot specified
Started
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Record History

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  1. Primary completion date: Feb 20, 2026 to Feb 20, 2027
    • Primary endpoints revised (2)
    • Study completion date: Jun 30, 2026 to Jun 30, 2027
    v3
  2. Start date changed from estimate of Feb 20, 2024 to Feb 11, 2024v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study explores the impact of long-term benzodiazepine (BZDs) use on cognitive function and associated neuroimaging markers. While BZDs are established treatments for conditions like anxiety and insomnia, recent warnings highlight risks, including neurocognitive effects. Neuroimaging studies indicate potential neuroprotective effects of BZDs. Functional near-infrared spectroscopy (fNIRS) measures cerebral cortex function during cognitive tasks. Combining fNIRS with mood and cognitive scales, this study assesses cortical activation. 2-deoxy-2-fluoro-D-glucose-positron emission tomography (FDG-PET) evaluates brain metabolism. DPA-714 PET assesses neuroinflammation. The primary objective is to compare brain functional activation, metabolism, and neuroinflammatory levels between long-term BZD users and non-users. This comprehensive approach aims to provide insights into BZD effects on cognition and associated brain markers.
Trial Details
NCT Number NCT06250842
Lead Sponsor The First Affiliated Hospital of Dalian Medical University
Conditions
(from sponsor)		 Benzodiazepine Adverse Reaction, Depression, Anxiety, Benzodiazepine Dependence
Related terms Anxiety Disorders, Depression, Long Term Adverse Effects
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov