Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

This study is being done to answer the following question: Is the strategy to give higher doses of radiotherapy treatment over a shorter period of time using special equipment and fewer treatments (also known as Stereotactic Body Radiation Therapy or SBRT) as effective as usual external radiation therapy given with a brachytherapy boost (which involves radiation sources inserted directly into the prostate)?

NCT Number	NCT06235697
Lead Sponsor	Canadian Cancer Trials Group Collaborators: NRG Oncology
Conditions	Prostate Cancer
Enrollment	710 participants
Start Date	2024-04-25
Primary Completion	2032-10-31 (estimated)
Study Completion	2033-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-14