Cemiplimab With or Without Fianlimab to Treat Older Patients With Localized or Locally Advanced MSI-H Colorectal Cancer

[...] n informed consent document. Inclusion Criteria for Cohort C and D: Age ≥18 years. Eastern Cooperative Oncology Group (ECOG) p [...] emed a poor surgical candidate after evaluation by a surgeon or unwilling to undergo surgery. Must not have received any prior systemic treatment or rad [...] low the study schedule for any reason Exclusion for Cohort C and D: Have received an investigational agent or used an investig [...] ng corneal allograft. Patient is pregnant or breastfeeding. Cohort D Only: Troponin T (TnT) or troponin I (TnI) > 2x institutional ULN at baseline. Conditions, including alcohol or drug dependence [...]

Inclusion Criteria for Cohort A and B: Age ≥70 years. Eastern Cooperative Oncology Group (ECOG) p [...] defined by study-specified laboratory tests and procedures. LVEF assessment with documented LVEF ≥ 45% by either TTE or MUGA (TTE preferred) within 6 months from first study drug administration. For both Women and Men, must use acceptable form of birth co [...] nd willingness to sign a written informed consent document. Inclusion Criteria for Cohort C: Age ≥18 years. Eastern Cooperative Oncology Group (ECOG) performance status 0 -3. Have histologically proven localized or locally advanced mismatch repair [...] [...]