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Domain-specific Aerobic Exercise Training in Coronary Artery Disease

Study acronym: DOSE-EX-CAD
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 11 months later Aug 2026 → Aug 2027
See other at-risk trials from Western University, Canada

Record History

  1. Notable Primary completion pushed from Aug 2026 to Aug 2027
    • Study completion pushed from Mar 2027 to Mar 2028
    v4
  2. Notable Trial status: Not Yet Recruiting to Recruiting
    • Primary completion date: Aug 2025 to Aug 2026
    • Start date changed from estimate of May 2024 to Nov 1, 2024
    • Study completion date: Mar 2026 to Mar 2027
    v3
  3. Notable Start date: Mar 2024 to May 2024v2
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Exercise training in cardiac rehabilitation (rehab) is a key part of managing a patient with heart disease. It has been shown that cardiac patients who increase their aerobic ("cardio") fitness by exercise training live longer, have better quality of life, and stay out of hospitals more than patients who do not improve their aerobic fitness. The more a patient improves their aerobic fitness the greater the benefit. But it has been shown that more than half of patients do not improve their aerobic fitness even after participating in cardiac rehab. This may be related to how hard patients are asked to train (their training "intensity"). The way intensity is chosen in current programs is commonly based on a "one-size fits all" method that may not consider that different patients have different abilities. There are more personalized methods to determine training intensity that exist, but these have never been used in cardiac rehab. One method divides intensity into three zones (zone 1 = moderate intensity; zone 2 = heavy intensity; zone 3 = very high intensity) that are based on when an individuals' biological responses to exercise change. The purpose of this study is to see if this approach gives better results in terms of changes in aerobic fitness and if training in the different zones makes a difference. Three groups of patients will be asked to train for 3 months in one of the three intensity zones. Aerobic fitness before and after exercise training will be compared to see which intensity zone results in the largest change.
Trial Details
NCT Number NCT06143332
Lead Sponsor Western University, Canada
Conditions
(from sponsor)
Coronary Artery Disease
Related terms Coronary Artery Disease
Enrollment 105 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov