Clinical Trial

Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome

Study acronym: PERFORM-CCS
Recruiting
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Summary
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires. Two hundred patients with abnormal perfusion will be randomized to immediate or delayed referral to invasive coronary angiography with concomitant optimization of guideline-directed medical therapy with repeated 15O-water PET and questionnaires at 3 and 6 months. The primary objective is to compare the potential benefit of early invasive coronary angiography (ICA) versus guideline directed medical therapy (GDMT) on symptomatic relief defined as freedom of angina after 3 months following a positive \[15O\]H2O cardiac PET/CT in patients with symptomatic chronic coronary syndrome.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2023-05-09; most recent amendment 2025-12-03.
Status change: Not Yet Recruiting → Recruiting 2023-05-23
Trial Details
NCT Number NCT05865600
Lead Sponsor Gødstrup Hospital
Conditions Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
Enrollment 570 participants
Start Date 2023-05-23
Primary Completion 2026-09-01 (estimated)
Study Completion 2027-09-01 (estimated)
Updated on ClinicalTrials.gov 2025-12-10