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Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome

Study acronym: PERFORM-CCS
StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated December 10, 2025 (before its estimated September 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Dec 1, 2024 to Sep 1, 2026
    • Study completion date: Sep 1, 2025 to Sep 1, 2027
    v3
  2. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    • Start date changed from estimate of May 10, 2023 to May 23, 2023
    v2
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires. Two hundred patients with abnormal perfusion will be randomized to immediate or delayed referral to invasive coronary angiography with concomitant optimization of guideline-directed medical therapy with repeated 15O-water PET and questionnaires at 3 and 6 months. The primary objective is to compare the potential benefit of early invasive coronary angiography (ICA) versus guideline directed medical therapy (GDMT) on symptomatic relief defined as freedom of angina after 3 months following a positive \[15O\]H2O cardiac PET/CT in patients with symptomatic chronic coronary syndrome.
Trial Details
NCT Number NCT05865600
Lead Sponsor Gødstrup Hospital
Conditions
(from sponsor)		 Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
Related terms Angina Pectoris, Angina, Stable, Coronary Artery Disease, Myocardial Ischemia
Enrollment 570 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov