Tadalafil for Severe Pulmonary Hypertension Due to Chronic Obstructive Pulmonary Disease

Inclusion Criteria: Patients ≥ 18 and <8085 years at inclusion, Dyspnea WHO functional class II to IV, [...] vernosal fibrosis, Peyronie's disease or history of priapism Pulmonary or upper respiratory infection requiring antibiotics, or pulmonary embolism in the last 4 weeks before screening Participation in a respiratory rehabilitation program within the 4 weeks prior to screening or scheduled during the study period Right heart failure necessitating catecholamine [...]

Inclusion Criteria: Patients >≥ 18 and <80 years at inclusion, Dyspnea WHO functional class [...] nsion defined by : a mean pulmonary artery pressure (mPAP) >35 mmHg or mPAP ≥25 mmHg with a cardiac index < 2.5 L/min/m²20 associated with normal pulmonary artery wedge pressure (PawP ≤15 mmHg) and pulmonary vascular resistance (PVR) >35 WU COPD diagnosed according to current international recomm [...] vital capacity (FVC): FEV1/FVC < 0.70, Naive patients from PDE5i (sildenafil, tadalafil) PH treatments and who did not receive other specific PH treatmentstreatment in the last 3 months (bosentan, ambrisentan, [...] [...]