Clinical Trial

Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation

Recruiting Phase 3
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Summary
To compare the outcomes of and responses to 2 different radiation therapy schedules (the standard radiation amount and number of doses versus less radiation and fewer doses) that are being given before having breast cancer surgery (cancer removal and reconstruction).
Protocol Amendment History 10 amendments
This ClinicalTrials.gov record has been amended 10 times since 2023-03-15; most recent amendment 2026-06-19.
Status change: Not Yet Recruiting → Recruiting 2023-04-06
Trial Details
NCT Number NCT05774678
Lead Sponsor M.D. Anderson Cancer Center
Collaborators: Artidis
Conditions Breast Cancer
Enrollment 126 participants
Start Date 2023-04-05
Primary Completion 2026-11-01 (estimated)
Study Completion 2028-11-01 (estimated)
Updated on ClinicalTrials.gov 2026-06-23