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A Clinical Trial of PRAX-222 in Pediatric Participants With Early Onset SCN2A Developmental and Epileptic Encephalopathy

StatusActive, Not Recruiting
PhasePhase 1/2
Started2023-04-13
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 7 months later Aug 2025 → Apr 1, 2026
See other at-risk trials from Praxis Precision Medicines

Amendment history

2026-07-31
Study Status, Contacts/Locations v4
Enrollment closed, study ongoing
Primary completion pushed: 2025-08 → 2026-04-01
Completion pushed: 2027-09 → 2028-02
Study sitesdetails revised at 3 of 3 sites
2025-08-15
Study Identification, Study Status, Oversight, Contacts/Locations v3
Study sites2→3
Study titlerevised
A Clinical Trial of PRAX-222 in Pediatric Participants withWith Early Onset SCN2A Developmental and Epileptic Encephalopathy
2024-10-02
Active, Not Recruiting→Recruiting Study Identification, Study Status, Oversight, Contacts/Locations v2
Trial statusActive, Not Recruiting→Recruiting
Primary completion date2025-07→2025-08
Completion date2026-02→2027-09
Study sites1→2
Study titlerevised
A Clinical Trial of PRAX-222 in Pediatric Participants Withwith Early Onset SCN2A Developmental and Epileptic Encephalopathy
2024-01-08
Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v1
Trial statusRecruiting→Active, Not Recruiting
Start dateestimated 2023-02→confirmed 2023-04-13
Study sitesdetails revised at 1 of 1 site
2023-02-10
Original filing
The goal of this trial is to learn about the effect of PRAX-222 in pediatric participants with early onset SCN2A developmental and epileptic encephalopathy (DEE), aged 2 to 18 years.
Trial Details
NCT Number NCT05737784
Lead Sponsor Praxis Precision Medicines
Conditions SCN2A-DEE, Epilepsy
Enrollment 60 participants
Start Date 2023-04-13
Primary Completion 2026-04-01 (estimated)
Study Completion 2028-02 (estimated)
Updated on ClinicalTrials.gov 2026-08-03