Analysis of Muscular Properties in Patients With MFS and EDS

Study acronym: MUSCLE
StatusCompleted
PhaseNot specified
Started

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Record History

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  1. Trial completed
    • Study completion date changed from estimate of Jan 2026 to Jan 31, 2026
    • Eligibility criteria expanded, about 7 words
  2. Primary completion date: Sep 30, 2024 to Jul 30, 2025
    • Study completion date: Feb 28, 2025 to Jan 2026
    v5
  3. Trial status: Recruiting to Active, Not Recruiting
    • Primary completion date changed from estimate of Sep 2024 to Sep 30, 2024
    • Study completion date: Feb 2025 to Feb 28, 2025
    • Site details revised
    v4
  4. Re-verified, no change to tracked fieldsv3
  5. Start date changed from estimate of Feb 2023 to Feb 15, 2023v2
  6. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS). the main questions it aims to answer are: * To assess the ability to develop muscle strength; * Muscle and tendon morphology involved in muscle contractions/relaxation; * Neuromuscular functionality. Participants will be take part in the study by performing a test for the assessment of the neuromuscular activity (voluntary muscle contractions) and undergoing a muscle ultrasound for the study of muscles and tendons. Researchers will compare the two groups with a control group to see potential differences in the morphological and neuromuscular structures of syndromic patients.
Trial Details
NCT Number NCT05720923
Lead Sponsor IRCCS Policlinico S. Donato
Collaborators: University of Milan
Conditions
(from sponsor)		 Rare Diseases, Marfan Syndrome, Ehlers-Danlos Syndrome
Related terms Ehlers-Danlos Syndrome, Fatigue, Marfan Syndrome, Rare Diseases
Enrollment 65 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov