Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical care at the Division of Adolescent and Young Adult Medicine. Three consecutive groups will be run with approximately 8-10 participants in each group over the next year.

NCT Number	NCT05685368
Lead Sponsor	Children's Hospital Los Angeles Collaborators: University of Southern California & Children's Hospital Los Angeles (USC-CHLA)
Conditions	Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
Enrollment	66 participants
Start Date	2025-04-01
Primary Completion	2029-06-30 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-06