Imaging Biomarkers of Pancreatic Function and Disease

This study seeks to understand the performance of MRI to characterize pancreatitis and predict chronic complications (endocrine and exocrine) of pancreatitis. Through multiple aims, the investigators will benchmark MRI against relevant reference standards (e.g. endoscopic pancreatic function tests, laboratory data). The investigators will also characterize repeatability of the imaging findings and will work to develop methods to simplify and automate analysis of the MRI images. Research interventions depend on the Aim(s) participants enroll in but include: endoscopic pancreatic function testing (added on to clinically indicated upper GI endoscopy), blood tests, stool tests, gene sequencing, and survey completion. All participants will undergo research MRI examinations, a subset of which will include administration of intravenous secretin.

NCT Number	NCT05659147
Lead Sponsor	Children's Hospital Medical Center, Cincinnati Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Pancreatitis, Diabetes Mellitus
Enrollment	195 participants
Start Date	2023-01-18
Primary Completion	2026-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-03-18