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The Role of the Locus Coeruleus in Age-related Distractibility

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. 3 versions Re-verified since Jul 12, 2024, no change to tracked fieldsv4-v6
  2. Start date changed from estimate of Apr 1, 2023 to Apr 11, 2023v3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Start date: Nov 1, 2022 to Apr 1, 2023
    • Site details revised
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
A growing body of research has highlighted the importance of frontal regions, at both the functional and structural levels, in age-related declines in attentional and cognitive processing. However, the underlying neurobiological pathophysiological changes in the brain that contribute to these declines are still largely unclear. The objective of this proposal is to investigate neural mechanisms of age-related attentional distractibility, focusing on the neural circuit initiated from the locus coeruleus (LC). In the current proposal, the investigators will test the hypothesis that the neural disconnectivity of LC with the salience network (SN) drives failures of ignoring distractors in older adults. The investigators will examine how LC-SN connectivity is associated with selective attention performance, and how improved LC-SN connectivity through a cognitive training program may lead to improved attentional performance.
Trial Details
NCT Number NCT05574634
Lead Sponsor Virginia Polytechnic Institute and State University
Conditions
(from sponsor)		 Aging, Alzheimer Disease
Related terms Alzheimer Disease
Enrollment 200 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov