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NotablePrimary endpoint(s) modifiedInterventions modified · Eligibility criteria expanded, about 14 words · Secondary endpoints: details revised at 1 of 2 entries · 1 moreShow 4 more changesShow less
Interventions modified
Eligibility criteria expanded, about 14 words
Secondary endpoints: details revised at 1 of 2 entries
Study description revised
NotablePrimary completion date: Jul 1, 2026 to Jul 8, 2027Primary endpoints revised (2) · Completion date: Nov 17, 2026 to Nov 10, 2027 · Interventions: sham (Device), tcVNS (Device) to Sham (Device), tcVNS (Device) · 2 morev6Show 5 more changesShow less
Primary endpoints revised (2)
Completion date: Nov 17, 2026 to Nov 10, 2027
Interventions: sham (Device), tcVNS (Device) to Sham (Device), tcVNS (Device)
MinorCompletion date: Sep 15, 2026 to Nov 17, 2026v5
MinorRe-verified, no change to tracked fieldsv4
MinorSite details revisedv3
NotableTrial status: Not Yet Recruiting to RecruitingSite details revisedv2Show 1 more changeShow less
Site details revised
MinorStudy First Submitted
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study effects the effects of transcutaneous cervical vagal nerve stimulation (tcVNS) or a sham control on brain, physiology, and PTSD symptoms in Veterans with posttraumatic stress disorder (PTSD). Veterans undergo brain imaging and physiological measures in conjunction with traumatic scripts before and after three months of twice daily treatment with tcVNS or sham stimulation at home.