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BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease

Study acronym: BEACON
StatusActive, Not Recruiting
PhasePhase 1/2
Started
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Record History

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  1. Primary completion date: Feb 1, 2025 to Feb 2028v13 Show 4 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Study sites: 20 to 19
    • Study completion date: Feb 1, 2027 to Feb 2028
    • Eligibility criteria shortened, about 24 words
  2. Study sites: 15 to 20v12
  3. Re-verified, no change to tracked fieldsv11
  4. Study sites: 13 to 15v10
  5. Study sites: 10 to 13v9
Show 7 earlier versionsHide 7 earlier versions
  1. Study sites: 8 to 10v8
  2. Study sites: 5 to 8v7
  3. Study sites: 4 to 5v6
  4. Study sites: 3 to 4v5
  5. Study sites: 2 to 3v4
  6. Study sites: 1 to 2v3
  7. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Aug 1, 2022 to Aug 30, 2022
    • Site details revised
    v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Trial Details
NCT Number NCT05456880
Lead Sponsor Beam Therapeutics Inc.
Conditions
(from sponsor)		 Sickle Cell Disease
Related terms Anemia, Sickle Cell
Enrollment 15 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov