Comparisons of Metabolic Effect of Sleeve Gastrectomy With Duodenojejunal Bypass and Sleeve Gastrectomy (MEDUSA): A Multicenter Randomized Controlled Trial

In this study, the effects of SG with DJB and SG alone for the treatment of type 2 diabetes mellitus (T2DM) will be compared in patients other than the two groups at both extremes who are expected to show excellent effects of metabolic surgery with SG alone (mild T2DM) and who need SG with DJB (severe T2DM). This study is to target patients with poor blood sugar control despite current medical treatment, although the beta-cell function of the pancreas is preserved. Therefore, this study is aimed at patients who have been using insulin for less than 10 years with T2DM, or taking diabetic medications with HbA1c ≥ 7.0% for less than 10 years with T2DM. The investigators hypothesize that the treatment effects of SG with DJB for T2DM will be superior to that of SG in this group

NCT Number	NCT05211375
Lead Sponsor	Seoul National University Bundang Hospital Collaborators: Ajou University School of Medicine, The Catholic University of Korea, The Catholic University of Korea Eunpyeong St. Mary's Hospital, Ewha Womans University Seoul Hospital, Seoul Metropolitan Boramae Hospital, Soonchunhyang University Hospital, Korea University
Conditions	Diabetes Mellitus, Type 2, Bariatric Surgery, Surgical Procedures, Operative, Asians
Enrollment	130 participants
Start Date	2022-01-03
Primary Completion	2031-01-03 (estimated)
Study Completion	2036-01-03 (estimated)
Updated on ClinicalTrials.gov	2022-01-27