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NCT05090540 · ClinicalTrials.gov record · last posted 2026-05-19

Transcatheter Versus Standard Surgical Mitral Valve Operation for Secondary Mitral Regurgitation

Study acronym: TEERMISO
StatusEnrolling by Invitation
PhaseNot specified
Started2017-06-01
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from the ClinicalTrials.gov record
The mechanical intervention is treating secondary mitral regurgitation (SMR) which may be performed using the standard open surgical approach or transcatheter edge to edge repair (TEER). The key question of this study is to establish the difference in left ventricular reverse remodeling after adjustment for death, as assessed by means of the left ventricular end-systolic dimension(LVESD), all-cause and cause-specific (cardiac vs noncardiac) mortality in patients who received the TEER vs the standard surgical procedure for SMR.

Amendment record 8 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 8 times since 2021-10-14; most recent amendment 2026-05-16. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

2023-05-30
Status change Active, Not Recruiting→Enrolling by Invitationv1
Trial Details
NCT Number NCT05090540
Lead Sponsor Centre Cardiologique du Nord
Collaborators: Campus Bio-Medico University, Henri Mondor University Hospital, Hokkaido University, University of Genova
Conditions Severe Mitral Valve Regurgitation (Disorder)
Enrollment 600 participants
Start Date 2017-06-01
Primary Completion 2024-03-01 (estimated)
Study Completion 2026-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-05-19