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Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis

StatusRecruiting
PhasePhase 2
Started2025-05-14
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 23 months later Jul 2026 → Jul 2028
See other at-risk trials from London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Amendment history

2026-10-02
Recruitment opened
Primary completion pushed: 2026-07 → 2028-07
Completion pushed: 2027-07 → 2029-07
2025-03-10
Study Status v6
Primary completion date2026-12→2026-07
Completion date2027-06→2027-07
Start date2025-06-01→2025-07-01
2024-11-21
Study Status, Oversight v5
Start date2024-09-01→2025-06-01
2024-02-23
Study Status v4
Primary completion date2025-12→2026-12
Completion date2026-06→2027-06
Start date2023-12-01→2024-09-01
2023-03-07
Study Status v3
Primary completion date2023-09→2025-12
Completion date2024-06→2026-06
Start date2022-09-01→2023-12-01
Show 2 earlier versions
2022-04-11
Study Status, Arms and Interventions v2
Primary completion date2023-03→2023-09
Start date2022-03→2022-09-01
InterventionsExtracorporeal Photopheresis (ECP) with Methoxsalen (Other)→Extracorporeal Photopheresis (ECP) (Device), UVADEX (Drug)
2021-11-24
Study Status v1
Primary completion date2023-09→2023-03
Completion date2024-03→2024-06
Start date2021-09→2022-03
2021-07-22
Original filing
The purpose of this study is to assess feasibility, safety and preliminary efficacy of Extracorporeal Photopheresis in the treatment of active diffuse cutaneous systemic sclerosis (dcSSc). This pilot study will help to determine if further study (a RCT) is justified.
Trial Details
NCT Number NCT04986605
Lead Sponsor London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Collaborators: Mallinckrodt
Conditions Diffuse Cutaneous Systemic Sclerosis
Enrollment 15 participants
Start Date 2025-05-14
Primary Completion 2028-07 (estimated)
Study Completion 2029-07 (estimated)
Updated on ClinicalTrials.gov 2026-10-01