Disease landscape

Scleroderma clinical trials

Get alerts when Scleroderma trials change

237 active trials 137 recruiting 14 Phase 3 159 sponsors 43 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-02

What changed in the last 30 days showing 34 of 43 changes on 20 trials

2026-09-09
Recruitment suspended
Recruitment suspended: temporarily suspended due to no new subjects at present
Completion pushed: 2027-12-30 → 2028-12-31
NCT06792344 Clinical Study of CD19 CAR-T in the Treatment of Refractory Systemic Sclerosis · The Children's Hospital of Zhejiang University School of Medicine · Phase 1
2026-09-29
Primary completion pushed: 2029-07 → 2030-09
Completion pushed: 2029-07 → 2030-09
NCT07038447 A Study of KITE-363 in Participants With Refractory Autoimmune Diseases · Kite, A Gilead Company · Phase 1
2026-09-09
Primary completion pushed: 2029-05-17 → 2029-08-30
Trial sites expanded: 131 → 134 locations
Completion pushed: 2029-07-12 → 2029-10-25
NCT05878717 A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis… · GlaxoSmithKline · Phase 2/3
2026-10-02
Primary completion pushed: 2026-07 → 2028-07
Recruitment opened
Completion pushed: 2027-07 → 2029-07
NCT04986605 Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Phase 2
2026-10-01
Trial completed
Final enrollment: 3 participants (planned 11)
Primary completion confirmed: July 2025 (last estimated February 2026)
NCT05149768 Open Label Extension Study of Brentuximab Vedotin in Early dcSSc · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Phase 2
2026-09-03
Enrollment closed, study ongoing
NCT06655896 Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous… · Novartis Pharmaceuticals · Phase 2
2026-09-16
Trial completed
Final enrollment: 238 participants (planned 300)
Primary completion confirmed: September 2026 (last estimated January 2027)
NCT06587828 A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in… · TScan Therapeutics, Inc.
2026-10-02
Start date pushed: 2026-10-10 → 2026-11-19
NCT07782450 A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune… · Pfizer · Phase 1/2
2026-09-24
Recruitment opened
NCT07301164 Clinical Study of BCT301 Cell Injection Therapy for Refractory Autoimmune Diseases · Peking University Third Hospital · Early Phase 1
2026-09-25
Completed without a posted recruiting period
Primary completion confirmed: September 2026 (last estimated April 2026)
NCT06646146 Study on the Efficacy of Autologous Fat Grafting in Improving Hair Transplantation… · Nanfang Hospital, Southern Medical University
2026-09-29
Primary completion pushed: 2026-09-01 → 2026-11-01
Completion pushed: 2026-09-01 → 2026-11-01
NCT04797286 Sildenafil for Early Pulmonary Vascular Disease in Scleroderma · Johns Hopkins University · Phase 2
2026-09-17
Enrollment closed, study ongoing
NCT07493395 Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to… · University Hospital, Montpellier · Phase 2
2026-09-18
Enrollment closed, study ongoing
NCT07339540 the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory… · Tongji Hospital · Early Phase 1
2026-09-11
Completed without a posted recruiting period
Final enrollment: 511 participants (planned 128)
NCT06373263 Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 · Lady Davis Institute
2026-09-04
Trial sites expanded: 246 → 249 locations
NCT07497087 A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis · Boehringer Ingelheim · Phase 3
2026-09-09
Trial sites expanded: 3 → 11 locations
NCT07641634 A Phase 1/2 Study of PRO-203 in Healthy Volunteers and Participants With Systemic… · Prolium Bioscience, Inc · Phase 1/2
2026-09-23
Completion moved earlier: 2029-07-31 → 2026-11-16
NCT05270668 Phase 2 Safety and Efficacy Study of Tulisokibart (MK-7240/PRA023) in Subjects With… · Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) · Phase 2
2026-09-16
Trial sites expanded: 8 → 11 locations
NCT03582800 Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications… · University Hospital, Limoges · Phase 2
2026-09-03
Primary completion confirmed: March 2026 (last estimated June 2026)
NCT02682511 Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated… · Cumberland Pharmaceuticals · Phase 2
2026-09-06
Trial status changed: Recruiting → Unknown
NCT06056921 Safety and Efficacy of CD19 Targeted CAR-T Therapy for Refractory Autoimmune Disease · Chongqing Precision Biotech Co., Ltd · Phase 1

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-09-30 NCT07849673 Improving ILD Screening in Patients With RA and SSc Using EHR-Embedded CDS and PRO Tools Foundation for Advancing Science Technology Education and Research new
2026-09-24 NCT07837986 Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases… Hospices Civils de Lyon new
2026-09-15 NCT07821398 Hyperpolarized Xenon MRI in Adults With Pulmonary Hypertension in Interstitial Lung… Bastiaan Driehuys new Phase 2
2026-09-14 NCT07817160 Pelvic Floor Dysfunction in Pulmonary Systemic Sclerosis Biruni University new
2026-09-08 NCT07806045 Nebulized UC-EVs for Recurrent or Refractory IMIDs With Lung Involvement Qiubai Li new Early Phase 1
2026-08-24 NCT07782450 A Study to Learn About a Medicine Called PF-08154225 in Participants With Autoimmune… Pfizer new Phase 1/2
2026-08-21 NCT07778446 A Study to Test CRT-402 in Refractory Autoimmune Disease Myeloid Therapeutics new Phase 1/2
2026-08-05 NCT07748000 A Study of LIQ861 (Inhaled Treprostinil) in Adults With Systemic Sclerosis Who Have… Liquidia Technologies, Inc. new Phase 2
2026-08-04 NCT07745725 A Phase II Study of TollB-001 Tablets in Systemic Sclerosis Toll Biotech Co. Ltd. (Beijing) new Phase 2
2026-07-29 NCT07734012 Mycophenolate After Stem Cell Transplant for Systemic Sclerosis Ottawa Hospital Research Institute new Phase 2

Active trials by phase

Early Phase 1
23
Phase 1
40
Phase 1/2
19
Phase 2
33
Phase 2/3
3
Phase 3
11
Phase 4
4
Not charted: 104 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 237

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07087912 Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in… University of Sao Paulo General Hospital Recruiting 2026-07-20
NCT05879419 Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases University of Sao Paulo General Hospital Active, Not Recruiting 2026-05-04
NCT05300932 A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis Tongji Hospital Active, Not Recruiting 2026-01-27
NCT06763783 Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases Region Skane Enrolling by Invitation 2025-01-10
Phase 3
NCT07497087 A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis Boehringer Ingelheim Recruiting 2026-09-30
NCT06549231 Evaluation of Efficacy and Safety of Rituximab and Mycophenolate Mofetil Combination in… University Hospital, Tours Recruiting 2026-06-12
NCT06297096 Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and… National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland Recruiting 2026-04-08
NCT07245238 Topical Cannabidiol Lotion for Pruritus Relief in Scleroderma Khon Kaen University Recruiting 2025-11-24
NCT06936215 Safety and Efficacy of Baricitinib on Skin Tightening in Diffuse Cutaneous Systemic… Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Recruiting 2025-04-20
NCT05925803 Determine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY) AstraZeneca Active, Not Recruiting 2026-09-30
NCT07335562 A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel /… Juno Therapeutics, Inc., a Bristol-Myers Squibb Company Not Yet Recruiting 2026-09-18
NCT07759557 Efficacy of A Non-Invasive Botulinum Toxin Microneedle Pad for the Treatment of Secondary… Khon Kaen University Not Yet Recruiting 2026-08-17
NCT07691970 Rollover Study for Participants Who Have Completed a Previous Clinical Study With… AstraZeneca Not Yet Recruiting 2026-07-09
NCT05726630 Clinical Study of Divozilimab in Patients With Systemic Scleroderma Biocad Active, Not Recruiting 2026-06-10
NCT05198557 A Study of MT-0551 in Patients With Systemic Sclerosis Tanabe Pharma Corporation Active, Not Recruiting 2025-12-08
Phase 2/3
NCT05878717 A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis… GlaxoSmithKline Recruiting 2026-09-08
NCT06328777 RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a… Cabaletta Bio Recruiting 2026-08-17
NCT05098704 Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk University Hospital, Bordeaux Recruiting 2026-07-07
Phase 2
NCT04986605 Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Recruiting 2026-10-01
NCT06954597 Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic… Topadur Pharma AG Recruiting 2026-10-01
NCT05785065 Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease Centre hospitalier de l'Université de Montréal (CHUM) Recruiting 2026-09-29
NCT04797286 Sildenafil for Early Pulmonary Vascular Disease in Scleroderma Johns Hopkins University Recruiting 2026-09-28
NCT06470048 A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic… Novartis Pharmaceuticals Recruiting 2026-09-28
NCT06655155 A Study to Assess the Efficacy and Safety of Efgartigimod PH20 SC in Adults With Systemic… argenx Recruiting 2026-09-24
NCT03582800 Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications… University Hospital, Limoges Recruiting 2026-09-15
See all 237 active Scleroderma trials with filters →

Top sponsors by active trials in this area

Assistance Publique - Hôpitaux de Paris (7) · Assiut University (6) · University Hospital, Strasbourg, France (6) · Beijing GoBroad Hospital (5) · Hacettepe University (5) · Institute of Hematology & Blood Diseases Hospital, China (4) · Peking University Third Hospital (4) · The Children's Hospital of Zhejiang University School of Medicine (4) · AstraZeneca (3) · China Immunotech (Beijing) Biotechnology Co., Ltd. (3)

Get alerts when Scleroderma trials change
Status changes, date slips, and new sponsor entrants: detected daily, delivered to your inbox.
Start monitoring free