Spanish Study for Molecular Characterization of Thyroid Carcinoma

Study acronym: MOLTHY
StatusUnknown
PhaseNot specified
Started

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Record History

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  1. Changed Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Active, Not Recruiting
  2. Study completion date: Mar 2024 to Mar 2025
    • Site details revised at 9 of 12 sites
    v5
  3. Trial status: Recruiting to Active, Not Recruiting
    • Primary completion date changed from estimate of Mar 2023 to Jan 25, 2023
    • Site details revised at 12 of 12 sites
    v4
  4. Site details revised at 12 of 12 sitesv3
  5. Study title shortened, about 4 wordsv2
  6. Study First Submitted
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This project is a retrospective observational study based on the molecular characterization of a Spanish population of patients with refractory radio-iodine differentiated thyroid cancer (DTC) and medullary thyroid carcinoma (MTC) with advanced and / or metastatic disease undergoing systemic treatment, or under clinical observation. Three diagnostic techniques will be performed on formalin-fixed paraffin embedded (FFPE) tumor samples from the study population: immunohistochemistry (IHC), fluorescence by in situ hybridization (FISH) as well as Next-Generation Sequencing (NGS) techniques by means of DNA and RNA analysis (Ion Platform Torrent - Oncomine Focus Assay, 52 gene detection). The results of each patient will be compared in order to correlate the results of each method.
Trial Details
NCT Number NCT04970134
Lead Sponsor Grupo Español de Tratamiento de Tumores de Cabeza y Cuello
Conditions
(from sponsor)		 Differentiated Thyroid Carcinoma, Medullary Thyroid Carcinoma
Related terms Carcinoma, Medullary
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov