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Effectivity and Safety of PFO Closure vs Medicine in Alleviating Migraine

Study acronym: SPRING
StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated March 12, 2025 (before its estimated September 6, 2025 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Jul 1, 2024 to Sep 6, 2025
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Jul 1, 2025 to Sep 6, 2025
    • Site details revised at 21 of 21 sites
    v4
  2. Trial status: Not Yet Recruiting to Recruitingv3 Show 4 more changesShow less
    • Primary completion date: Dec 1, 2023 to Jul 1, 2024
    • Study sites: 1 to 21
    • Study completion date: Dec 1, 2024 to Jul 1, 2025
    • Start date changed from estimate of Jul 15, 2021 to Aug 12, 2021
  3. Secondary endpoints revised (3)v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Effectivity and safety of PFO closure vs medicine in alleviating migraine （SPRING）: a multicenter, random, case control study
Trial Details
NCT Number NCT04946734
Lead Sponsor Guangdong Provincial People's Hospital
Conditions
(from sponsor)		 PFO - Patent Foramen Ovale, Migraine
Related terms Foramen Ovale, Patent, Migraine Disorders
Enrollment 440 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov