Clinical Trial

Effectivity and Safety of PFO Closure vs Medicine in Alleviating Migraine

Study acronym: SPRING
Active, Not Recruiting Phase 3
View on ClinicalTrials.gov →
Record status
This record was last updated March 12, 2025 (before its estimated September 6, 2025 completion). Its status may not reflect the trial's current state.
Summary
Effectivity and safety of PFO closure vs medicine in alleviating migraine （SPRING）: a multicenter, random, case control study
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2021-06-23; most recent amendment 2025-03-09.
Status change: Recruiting → Active, Not Recruiting 2025-03-09
Status change: Not Yet Recruiting → Recruiting 2023-12-16
Trial Details
NCT Number NCT04946734
Lead Sponsor Guangdong Provincial People's Hospital
Conditions PFO - Patent Foramen Ovale, Migraine
Enrollment 440 participants
Start Date 2021-08-12
Primary Completion 2025-09-06 (estimated)
Study Completion 2025-09-06 (estimated)
Updated on ClinicalTrials.gov 2025-03-12