SBRT + Atezolizumab + Bevacizumab in Resectable HCC

StatusActive, Not Recruiting
PhaseEarly Phase 1
Started

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Record History

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  1. Primary completion date changed from estimate of Apr 29, 2026 to Mar 13, 2026
    • Study completion moved earlier from Apr 29, 2027 to Dec 31, 2026
    • Eligibility criteria expanded, about 58 words
  2. Primary completion date: Dec 31, 2024 to Apr 29, 2026
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Dec 31, 2025 to Apr 29, 2027
    • Site details revised
    v5
  3. Site contact updatedv4
  4. Re-verified, no change to tracked fieldsv3
  5. Trial status: Not Yet Recruiting to Recruitingv2 Show 4 more changesShow less
    • Primary completion date: Jun 30, 2024 to Dec 31, 2024
    • Study completion date: Dec 1, 2025 to Dec 31, 2025
    • Start date changed from estimate of Aug 2021 to Jun 18, 2021
    • Site details revised
  6. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study is evaluating the safety and tolerability of neoadjuvant stereotactic body radiation therapy (SBRT) with atezolizumab and bevacizumab for treating resectable hepatocellular carcinoma. This study involves the following study interventions: * Atezolizumab * Bevacizumab * Stereotactic Beam Radiation Therapy (SBRT) * Surgery
Trial Details
NCT Number NCT04857684
Lead Sponsor Massachusetts General Hospital
Collaborators: Genentech, Inc.
Conditions
(from sponsor)		 Hepatocellular Carcinoma, Resectable Hepatocellular Carcinoma
Related terms Carcinoma, Hepatocellular
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov