De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.

NCT Number	NCT04852887
Lead Sponsor	NRG Oncology Collaborators: National Cancer Institute (NCI)
Conditions	Stage I Breast Cancer
Enrollment	1,670 participants
Start Date	2021-06-23
Primary Completion	2031-04-08 (estimated)
Study Completion	2041-07 (estimated)
Updated on ClinicalTrials.gov	2026-04-23