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Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial

Study acronym: CorCMR
StatusActive, Not Recruiting
PhaseNot applicable
Started
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Record History

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  1. Study sites: 1 to 3v3
  2. Primary completion date changed from estimate of Feb 2024 to Oct 1, 2024v2 Show 4 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Feb 2024 to Oct 1, 2034
    • Site details revised
    • Publications: 16 to 19
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected. Recent advances in quantifying myocardial blood flow using stress perfusion cardiac magnetic resonance imaging (CMR) has potential for accurate detection coronary microvascular dysfunction. The CorCMR diagnostic study involves stress perfusion CMR in patients with suspected INOCA to clarify the prevalence of subgroups of patients with underlying problems, such as microvascular disease or undisclosed obstructive coronary artery disease, that might explain their anginal symptoms. A nested, prospective, randomised, controlled, double-blind trial will determine whether stratified medical therapy guided by the results of the stress perfusion CMR improves symptoms, well-being, cardiovascular risk and health and economic outcomes.
Trial Details
NCT Number NCT04805814
Lead Sponsor NHS National Waiting Times Centre Board
Collaborators: University of Glasgow, British Heart Foundation, Chief Scientist Office of the Scottish Government
Conditions
(from sponsor)		 Microvascular Angina, Angina Pectoris, Angina, Stable, Non-Obstructive Coronary Atherosclerosis, Small Vessel Cerebrovascular Disease, Coronary Artery Disease
Related terms Angina Pectoris, Angina, Stable, Cerebral Small Vessel Diseases, Coronary Artery Disease, Microvascular Angina
Enrollment 280 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov