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Cardiac Rehab Effects in HFpEF

StatusCompleted
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial completed Eligibility criteria expanded, about 2 words Show 1 more changeShow less
    • Eligibility criteria expanded, about 2 words
  2. Re-verified, no change to tracked fieldsv10
  3. Trial status: Recruiting to Active, Not Recruiting Enrollment target: estimated 60 to confirmed 45 · Site details revisedv9 Show 2 more changesShow less
    • Enrollment target: estimated 60 to confirmed 45
    • Site details revised
  4. Primary completion date: Sep 30, 2025 to Sep 30, 2026 Enrollment target: 50 to 60v8 Show 1 more changeShow less
    • Enrollment target: 50 to 60
  5. Site contact updatedv7
Show 5 earlier versionsHide 5 earlier versions
  1. Site details revisedv6
  2. Trial status: Not Yet Recruiting to Recruiting Completion date: Sep 30, 2025 to Sep 30, 2026 · Site details revisedv5 Show 2 more changesShow less
    • Completion date: Sep 30, 2025 to Sep 30, 2026
    • Site details revised
  3. Primary and study completion dates: Sep 30, 2024 to Sep 30, 2025 Start date: May 3, 2021 to May 2, 2022 · Site contact updatedv4 Show 2 more changesShow less
    • Start date: May 3, 2021 to May 2, 2022
    • Site contact updated
  4. Start date: Feb 1, 2021 to May 3, 2021v3
  5. Start date: Nov 2, 2020 to Feb 1, 2021v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This research in Veterans with heart failure with preserved ejection fraction (HFpEF) will provide new information on the mechanisms determining the patients' exercise intolerance and the efficacy of regular physical activity to improve this shortcoming by alleviating the patients' neurocirculatory abnormalities. Specifically, the investigators will focus on the role of nerves originating in working limb muscles in determining the patients' exercise intolerance and compromised fatigue resistance before and after a chronic exercise intervention. By focusing on a specific mechanism, this project will evaluate the validity of exercise as an alternative treatment strategy with the overall purpose of improving the quality of life of Veterans with HFpEF.
Trial Details
NCT Number NCT04506606
Lead Sponsor VA Office of Research and Development
Conditions Heart Failure With Preserved Ejection Fraction
Enrollment 45 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov