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WaKING: Wnt and checKpoint INhibition in Gastric Cancer

StatusActive, Not Recruiting
PhasePhase 1/2
Started
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Record History

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  1. Primary completion date changed from estimate of Dec 30, 2024 to Mar 30, 2025
    • Study completion date: Sep 11, 2025 to Dec 31, 2025
    v8
  2. Primary completion date: May 30, 2024 to Dec 30, 2024
    • Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v7
  3. Re-verified, no change to tracked fieldsv6
  4. Primary completion date: Sep 11, 2022 to May 30, 2024
    • Site contact updated
    • Eligibility criteria expanded, about 1 word
    v5
  5. 2 versions Re-verified since Mar 9, 2021, no change to tracked fieldsv3-v4
  6. Trial status: Not Yet Recruiting to Recruitingv2 Show 4 more changesShow less
    • Primary completion date: Dec 2021 to Sep 11, 2022
    • Study completion date: Dec 2022 to Sep 11, 2025
    • Start date changed from estimate of Dec 2019 to Feb 11, 2020
    • Site details revised
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a multicentre open-label non-randomised, Single Stage Ahern Design (with a 3+3 design for the safety run-in) phase II clinical trial of DKN-01 plus atezolizumab in patients with advanced unresectable or metastatic OGA who have progressed following chemotherapy.
Trial Details
NCT Number NCT04166721
Lead Sponsor Royal Marsden NHS Foundation Trust
Conditions
(from sponsor)		 Metastatic Esophageal Cancer, Metastatic Gastric Cancer
Related terms Esophageal Neoplasms, Stomach Neoplasms
Enrollment 52 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov