Clinical Trial

A Randomized Comparison of CLOpidogrel Monotherapy Versus Extended Dual-antiplatelet Therapy Beyond 12 Months After Implantation of Drug-eluting StEnts in High-risk Lesions or Patients; A-CLOSE Trial

Active, Not Recruiting Phase 4
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Record status
This record was last updated October 24, 2024 (before its estimated August 16, 2025 completion). Its status may not reflect the trial's current state.
Summary
We hypothesized that clopidogrel mono-therapy will not be inferior to the extended DAPT in terms of the occurrence of both ischemic and bleeding events, for lesions or patients at high risk for either ischemic or bleeding complications 12 months after drug-eluting stent (DES) implantation.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2019-05-10; most recent amendment 2024-10-21.
Status change: Recruiting → Active, Not Recruiting 2023-11-08
Status change: Not Yet Recruiting → Recruiting 2019-08-21
Trial Details
NCT Number NCT03947229
Lead Sponsor Yonsei University
Conditions Coronary Artery Disease, DES
Enrollment 3,200 participants
Start Date 2019-08-14
Primary Completion 2025-08-16 (estimated)
Study Completion 2026-08-16 (estimated)
Updated on ClinicalTrials.gov 2024-10-24