Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone Treatment

Patients undergoing first time cardiac surgery will undergo rapid atrial pacing prior to initiation of cardiopulmonary bypass to screen for AF inducibility. Patients with inducible AF will be randomized to prophylactic amiodarone treatment versus no treatment. Patients who are not inducible to AF will be treated with standard post-operative care. Patients will be monitored post-operatively to explore the value of intraoperative inducibility of AF to predict POAF and to evaluate whether the combination of intraoperative inducibility and precision amiodarone therapy is effective at reducing the incidence of POAF

NCT Number	NCT03868150
Lead Sponsor	Stanford University
Conditions	Postoperative Atrial Fibrillation
Enrollment	600 participants
Start Date	2017-03-01
Primary Completion	2030-12-31 (estimated)
Study Completion	2050-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-17