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Preventing Alzheimer's With Cognitive Training

Study acronym: PACT
StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 2 years later Jan 31, 2026 → Jan 31, 2028
See other at-risk trials from University of South Florida

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary and study completion pushed from Jan 31, 2026 to Jan 31, 2028
    • Enrollment closed, study ongoing
    • Site details revised at 7 of 7 sites
    v16
  2. Study sites: 5 to 7v15
  3. Re-verified, no change to tracked fieldsv14
  4. Study sites: 7 to 5v13
  5. Secondary endpoints shortened, about 18 words
    • Study description expanded, about 1 word
    • Study title shortened, about 1 word
    v12
Show 10 earlier versionsHide 10 earlier versions
  1. Phase: Not applicable to Phase 3v11
  2. Primary completion date: Jul 30, 2026 to Jan 31, 2026
    • Study completion date: Jan 30, 2027 to Jan 31, 2026
    • Eligibility criteria expanded, about 2 words
    v10
  3. Primary completion date: Jan 30, 2027 to Jul 30, 2026v9
  4. Study sites: 2 to 7v8
  5. Trial status: Active, Not Recruiting to Recruiting
    • Site details revised at 2 of 2 sites
    v7
  6. Enrollment target: 1600 to 7600v6 Show 5 more changesShow less
    • Primary and study completion dates: Oct 30, 2025 to Jan 30, 2027
    • Primary endpoint revised
    • Secondary endpoints: details revised at 1 of 1 entry
    • Study description shortened, about 75 words
    • Collaborators: 2 to 1
  7. Primary completion date: Mar 30, 2020 to Oct 30, 2025v5 Show 4 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Jun 30, 2020 to Oct 30, 2025
    • Site details revised at 2 of 2 sites
    • Eligibility criteria shortened, about 2 words
  8. Study description shortened, about 184 wordsv4
  9. Site details revised at 1 of 2 sitesv3
  10. Start date changed from estimate of Feb 20, 2019 to Feb 19, 2019
    • Site details revised at 1 of 2 sites
    v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and is indicative of higher risk for dementia. In addition to the obvious health and quality-of-life ramifications of dementia, there are high direct (e.g., subsidizing residential care needs) and indirect (e.g., lost productivity of family caregivers) economic costs. Implementing interventions to prevent MCI and dementia among older adults is of critical importance to health and maintained quality-of-life for millions of Americans. Recent data analyses from the Advanced Cognitive Training in Vital Elderly study (ACTIVE) indicate that a specific cognitive intervention, speed of processing training (SPT), significantly delays the incidence of cognitive impairment across 10 years. The primary contribution of the proposed research will be the determination of whether this cognitive training technique successfully delays the onset of clinically defined MCI or dementia across three years.
Trial Details
NCT Number NCT03848312
Lead Sponsor University of South Florida
Collaborators: National Institute on Aging (NIA)
Conditions
(from sponsor)		 Age-related Cognitive Decline, Alzheimer's Disease and Related Dementias
Related terms Alzheimer Disease
Enrollment 7,600 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov