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Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 10 months later Dec 2025 → Nov 2026
See other at-risk trials from University Health Network, Toronto

Record History

  1. Primary completion pushed from Dec 2025 to Nov 2026 Enrollment closed, study ongoing · Completion date: Dec 2030 to Nov 15, 2030 · Eligibility criteria expanded, about 24 words · 2 more Show 5 more changesShow less
    • Enrollment closed, study ongoing
    • Completion date: Dec 2030 to Nov 15, 2030
    • Eligibility criteria expanded, about 24 words
    • Site details revised
    • Publications: details revised at 1 of 1 entry
  2. Primary completion date: Sep 2025 to Dec 2025 Completion date: Dec 2025 to Dec 2030v11 Show 1 more changeShow less
    • Completion date: Dec 2025 to Dec 2030
  3. Re-verified, no change to tracked fieldsv10
  4. Primary completion date: Sep 2023 to Sep 2025 Completion date: Dec 2023 to Dec 2025v9 Show 1 more changeShow less
    • Completion date: Dec 2023 to Dec 2025
  5. Eligibility criteria shortened, about 13 wordsv8 See this version in full on ClinicalTrials.gov ↗
Show 6 earlier versionsHide 6 earlier versions
  1. Re-verified, no change to tracked fieldsv7
  2. Start date: Aug 2016 to Aug 3, 2016 Eligibility criteria shortened, about 2 wordsv6 Show 1 more changeShow less
    • Eligibility criteria shortened, about 2 words

    See this version in full on ClinicalTrials.gov ↗

  3. Eligibility criteria expanded, about 5 wordsv5 See this version in full on ClinicalTrials.gov ↗
  4. 2 versions Re-verified since Dec 1, 2016, no change to tracked fieldsv3-v4
  5. Eligibility criteria expanded, about 14 words Site contact updatedv2 Show 1 more changeShow less
    • Site contact updated

    See this version in full on ClinicalTrials.gov ↗

  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Patients with unresectable liver metastases (LM) from colorectal cancer (CRC)have a poor prognosis. In patients with resectable disease, surgery offers a distinct survival benefit. This study will offer live donor liver transplantation (LDLT) to select patients with unresectable metastases that are 1) limited to the liver and 2) stable (non-progressing) on standard chemotherapy. Potential participants will be evaluated for liver transplant suitability and must also have a willing, healthy living donor come forward for evaluation. Those participants who undergo LDLT will be followed for survival, disease-free survival and quality of life for 5 years and compared to a "control group" of participants who drop out of study prior to transplantation due to reasons other than cancer progression.
Trial Details
NCT Number NCT02864485
Lead Sponsor University Health Network, Toronto
Conditions Colorectal Cancer, Liver Metastases
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov