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Combination Chemotherapy, Radiation Therapy, and Bevacizumab in Treating Patients With Newly Diagnosed Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

StatusActive, Not Recruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Amendment history

The 50 most recent of 245 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Minor

    2 amendments

    2 re-verifications since 2026-07-07, no change to tracked fields

    v244-v245

  2. Minor

    Study sites revised (61)

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    MUT DMD Anderson Cancer Center

    Study Status, Arms and Interventions, Contacts/Locationsv243

  3. Minor

    Study sites: 62 to 61

    Study Status, Contacts/Locationsv242

  4. Minor

    Study sites: 63 to 62

    Completion date: Feb 22, 2026 to Feb 22, 2027

    Study Status, Contacts/Locationsv241

  5. Minor

    Study Status

    Re-verified, no change to tracked fields

    v240

Show 44 earlier versions

  1. Minor

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    StewardDana-Farber SaintCancer Elizabeth'sInstitute at Boston Medical Center - Brighton

    Study Status, Contacts/Locationsv239

  2. Minor

    Completion date: Feb 22, 2025 to Feb 22, 2026

    Study Statusv238

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    2 amendments

    2 re-verifications since 2024-12-03, no change to tracked fields

    v236-v237

  4. Minor

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    SouthwestBallad VA RegionalHealth Cancer CenterCare - Norton

    Study Status, Contacts/Locationsv235

  5. Minor

    2 amendments

    2 re-verifications since 2024-07-02, no change to tracked fields

    v233-v234

  6. Minor

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    Benefis Healthcare- Sletten Cancer Institute

    Study Status, Contacts/Locationsv232

  7. Minor

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    HaysMed University of Kansas Health System

    Study Status, Contacts/Locationsv231

  8. Minor

    Study Status, Arms and Interventions

    Re-verified, no change to tracked fields

    v230

  9. Minor

    Completion date: Feb 22, 2025

    Study Statusv229

  10. Minor

    Study Status, Arms and Interventions

    Re-verified, no change to tracked fields

    v228

  11. Minor

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    UCHealth University of Colorado Hospital

    Study Status, Arms and Interventions, Contacts/Locationsv227

  12. Minor

    4 amendments

    4 re-verifications since 2022-11-16, no change to tracked fields

    v223-v226

  13. Minor

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    Highlands Oncology Group - Rogers

    Study Status, Contacts/Locationsv222

  14. Minor

    4 amendments

    4 re-verifications since 2021-10-23, no change to tracked fields

    v218-v221

  15. Minor

    Study sites revised (63)

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    Providence Santa Rosa Memorial Hospital

    Study Status, Contacts/Locationsv217

  16. Minor

    2 amendments

    2 re-verifications since 2021-07-30, no change to tracked fields

    v215-v216

  17. Minor

    Study sites: 62 to 63

    Study Status, Contacts/Locationsv214

  18. Minor

    7 amendments

    7 re-verifications since 2020-10-14, no change to tracked fields

    v207-v213

  19. Minor

    Study sites revised (62)

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    Highlands Oncology Group-Rogers

    Study Status, Contacts/Locationsv206

  20. Minor

    Study Status, Arms and Interventions

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    v205

  21. Minor

    Study sites revised (62)

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    HaysHaysMed MedicalUniversity Centerof Kansas Health System University of Kansas Health System Saint Francis Hospital and Medical Center - TopekaCampus

    Study Status, Contacts/Locationsv204

  22. Minor

    2 amendments

    2 re-verifications since 2020-04-11, no change to tracked fields

    v202-v203

  23. Minor

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    Louisiana State UniversityLSU Health Sciences Center at Shreveport

    Study Status, Contacts/Locationsv201

  24. Minor

    5 amendments

    5 re-verifications since 2019-11-18, no change to tracked fields

    v196-v200

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This clinical trial studies combination chemotherapy, radiation therapy, and bevacizumab in treating patients with newly diagnosed stage III non-small cell lung cancer that cannot be removed by surgery. Drugs used in chemotherapy, such as cisplatin, etoposide, and docetaxel, work in different ways to stop the growth of \[cancer/tumor\] cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving more than one drug (combination chemotherapy) together with radiation therapy and bevacizumab may kill more tumor cells.
Trial Details
NCT Number NCT00334815
Lead Sponsor National Cancer Institute (NCI)
Conditions Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Lung Large Cell Carcinoma, Lung Squamous Cell Carcinoma, Minimally Invasive Lung Adenocarcinoma, Stage IIIA Lung Non-Small Cell Cancer AJCC v7, Stage IIIB Lung Non-Small Cell Cancer AJCC v7
Enrollment 29 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov