Studies of Frontal Lobe Brain Functioning in Schizophrenia

StatusCompleted
PhaseNot specified
Started

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Record History

The 50 most recent of 285 record versions are accounted for below. See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fields
  2. Eligibility criteria expanded, about 1 word
  3. 2 versions Re-verified since Aug 6, 2026, no change to tracked fieldsv282-v283
  4. Study description revisedv281
  5. 43 versions Re-verified since Jan 20, 2024, no change to tracked fieldsv238-v280
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  1. Study Status, Study Descriptionv237
  2. Re-verified, no change to tracked fieldsv236
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers. Participants in this study will undergo a positron emission tomography (PET) scan of the brain while performing neuropsychological tests. Some of the tests involve cognitive operations that depend upon the frontal cortex. Interactions between frontal lobe activation, cognitive behavior, and neuropharmacology will be assessed by measuring regional cerebral blood flow (rCBF) during treatment with drugs that may affect frontal lobe physiology.
Trial Details
NCT Number NCT00001258
Lead Sponsor National Institute of Mental Health (NIMH)
Conditions
(from sponsor)		 Healthy Subjects, Schizophrenia, Parkinson Disease
Related terms Cognitive Dysfunction, Parkinson Disease, Psychotic Disorders, Schizophrenia
Enrollment 1,039 participants
Start Date
Updated on ClinicalTrials.gov