Sponsor pipeline

Rhythm Pharmaceuticals, Inc. clinical trial pipeline

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5 active trials 1 recruiting 2 Phase 3 1 disease areas 3 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-10-11

What changed in the last 30 days

1 trial changed in the last 30 days: 0 stopped, 0 with notable changes, 1 with a minor change only.

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

Active trials by phase

Phase 1/2
1
Phase 2
2
Phase 3
2

Active trials

NCT IDTitleConditionStatusUpdated
Phase 3
NCT06760546 A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of… Hypothalamic Obesity Recruiting 2026-02-12
NCT05774756 A Trial of Setmelanotide in Acquired Hypothalamic Obesity Hypothalamic Obesity Active, Not Recruiting 2026-08-10
Phase 2
NCT06772597 A Study of Setmelanotide in Patients With Prader-Willi Syndrome Prader-Willi Syndrome Active, Not Recruiting 2026-02-12
NCT07156578 A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO) Hypothalamic Obesity Enrolling by Invitation 2026-02-10
Phase 1/2
NCT06239116 A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment Hypothalamic Obesity Active, Not Recruiting 2026-10-09

Disease areas by active trials

Obesity (5)

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