Disease Landscape

Spinal Muscular Atrophy Clinical Trials

Data updated daily from ClinicalTrials.gov — last refresh 2026-08-16
82
Active Trials
43
Recruiting
10
Phase 3
62
Sponsors
2
Changes, 30 Days
What Changed in the Last 30 Days
DetectedTrialChange
2026-08-11 NCT07287982
A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and… · argenx
Trial sites expanded: 17 -> 24 locations
2026-08-02 NCT04292574
UK SMA Patient Registry · Newcastle University
overall status: Recruiting → Unknown
New Sponsor Entrants, Last 90 Days
First PostedTrialSponsorPhase
2026-07-22 NCT07720518 Spinal Muscular Atrophy and School Transitions Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust NEW
2026-06-01 NCT07617779 A Study of the Safety and Preliminary Efficacy of NKG001 in Pediatric Patients With Type… Nikegen Pharmaceutical (Hangzhou) Company Limited NEW
2026-05-19 NCT07596277 Exploring Lived Experiences of Families of Children With Spinal Muscular Atrophy(SMA)… Guy's and St Thomas' NHS Foundation Trust NEW
Active Trials by Phase
Phase 4
2
Phase 3
9
Phase 2/3
1
Phase 2
2
Phase 1/2
8
Early Phase 1
1
Not specified
59
Active Trials — top 25 of 82
NCT IDTitleSponsorStatus
Phase 4
NCT07448610 ASsessing The REAl-world Safety & Effectiveness of Spinal Muscular Atrophy Participants… Novartis Pharmaceuticals Not Yet Recruiting
NCT05232929 Long-term Follow-up Study of Risdiplam in Participants With Spinal Muscular Atrophy (SMA) Genentech, Inc. Active, Not Recruiting
Phase 3
NCT06971094 Safety and Efficacy Evaluation of GC101 Gene Therapy Via Intrathecal (IT) Injectionin the… GeneCradle Inc Recruiting
NCT07265232 Real World Clinical Effectiveness & Safety of Vesemnogene Lantuparvovec for Spinal… Lantu Biopharma Recruiting
NCT05331937 TMS for Exposure Therapy Resistant OCD Amsterdam UMC, location VUmc Recruiting
NCT07444476 A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety in… Biogen Recruiting
NCT04042025 Long-term Follow-up Study of Patients Receiving Onasemnogene Abeparvovec-xioi Novartis Gene Therapies Active, Not Recruiting
NCT05626855 Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous… Scholar Rock, Inc. Active, Not Recruiting
NCT05067790 A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as… Biogen Active, Not Recruiting
NCT05337553 A Study to Evaluate the Efficacy and Safety of Taldefgrobep Alfa in Participants With… Biohaven Pharmaceuticals, Inc. Active, Not Recruiting
NCT05335876 Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in… Novartis Pharmaceuticals Active, Not Recruiting
Phase 2/3
NCT05115110 A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam… Hoffmann-La Roche Active, Not Recruiting
Phase 2
NCT07047144 A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and… Scholar Rock, Inc. Recruiting
NCT07287982 A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and… argenx Recruiting
Phase 1/2
NCT05747261 Study of the Safety and Efficacy of an Adeno-Associated Viral Vector Carrying the SMN… Biocad Recruiting
NCT05824169 Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal… GeneCradle Inc Recruiting
NCT06421831 Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal… GeneCradle Inc Recruiting
NCT07070999 Study of Safety, Tolerability and Efficacy of GB221 in Infants With Spinal Muscular… Gemma Biotherapeutics Recruiting
NCT05614531 Clinical Trial to Assess the Safety and Efficacy of EXG001-307 in Patients with Spinal… Guangzhou Jiayin Biotech Ltd Enrolling by Invitation
NCT05901987 Evaluation of Safety and Efficacy of Gene Therapy Drug in the Treatment of Spinal… GeneCradle Inc Active, Not Recruiting
NCT07554924 A Phase I/II Clinical Study to Evaluate SKG0201 Injection in Subjects With Spinal… Lanyue Biotech (Hangzhou) Co., Ltd. Not Yet Recruiting
NCT06288230 An Open Label Study of Gene Therapy Product (Vesemnogene Lantuparvovec) in Spinal… Lantu Biopharma Active, Not Recruiting
Early Phase 1
NCT06888661 Clinical Trial to Assess the Safety and Efficacy of EXG001-307 in Patients With Spinal… Guangzhou Jiayin Biotech Ltd Enrolling by Invitation
Not specified
NCT04010604 A Registered Cohort Study on SMA Wan-Jin Chen Recruiting
NCT05663008 Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for… University of Dublin, Trinity College Recruiting
See all 82 active Spinal Muscular Atrophy trials with filters →
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