Disease landscape

NSCLC clinical trials

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1,327 active trials 698 recruiting 168 Phase 3 601 sponsors 194 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 49 of 194 changes on 20 trials

2026-08-15
critical
Recruitment suspended
Recruitment suspended: Placed on voluntary hold to new recruitment pending modification to combination monoclonal antibody treatment.
NCT06694454 Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab… · National Cancer Institute (NCI) · Phase 1/2
2026-08-04
critical
Trial status changed: Recruiting → Withdrawn
Trial withdrawn: Slow accrual
Enrollment reduced: 30 → 0 participants
NCT06124118 Tumor Treating Fields for Locally Advanced NSCLC · University of Utah · Phase 1
2026-08-26
notable
Primary completion pushed: 2025-06-30 → 2025-12-15
Completion pushed: 2027-12-30 → 2030-03-30
NCT05948813 TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases · TYK Medicines, Inc · Phase 2
2026-08-21
critical
Primary completion pushed: 2028-06-30 → 2029-12-31
Completion pushed: 2028-06-30 → 2029-12-31
NCT06494540 NIS to Examine the Effectiveness of TDC in Patients With Metastatic Non-squamous NSCLC… · AstraZeneca
2026-08-14
critical
Primary completion pushed: 2026-02 → 2027-08
Completion pushed: 2026-02 → 2027-08
NCT05276726 A Study of JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11… · Allist Pharmaceuticals, Inc. · Phase 1/2
2026-08-12
critical
Primary completion pushed: 2026-10 → 2027-09
Trial sites reduced: 32 → 19 locations
Completion pushed: 2026-10 → 2027-09
NCT05592626 A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion… · Marengo Therapeutics, Inc. · Phase 1/2
2026-08-12
critical
Primary completion pushed: 2025-06-30 → 2026-12-30
Sponsor changed: Evopoint Biosciences Inc. → Astellas Pharma Global Development, Inc.
Enrollment closed, study ongoing
Completion pushed: 2025-12-31 → 2027-06-30
NCT06792435 XNW27011 Study of Advanced Solid Tumor Subjects Who Failed Standard Therapies. · Astellas Pharma Global Development, Inc. · Phase 1/2
2026-08-05
notable
Primary completion pushed: 2026-07-30 → 2026-11-30
Completion pushed: 2026-07-30 → 2026-11-30
NCT05853575 Trial of Two Adagrasib Dosing Regimens in NSCLC With KRAS G12C Mutation (KRYSTAL 21) · Mirati Therapeutics Inc. · Phase 2
2026-07-30
critical
Primary completion pushed: 2025-11 → 2028-05
Primary endpoint(s) modified
Trial sites expanded: 45 → 54 locations
Completion pushed: 2027-11 → 2028-11
NCT03526835 A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors · Merus B.V. · Phase 1/2
2026-08-06
critical
Primary completion pushed: 2026-01-01 → 2027-01-01
Completion pushed: 2027-07-01 → 2028-07-01
NCT06473961 A Phase Ib Study of GC101 in NSCLC · Shanghai Juncell Therapeutics · Phase 1
2026-08-04
notable
Primary completion pushed: 2026-08-30 → 2026-11-30
Completion pushed: 2026-09-30 → 2026-11-30
NCT07680907 A Real World Study of Participants With Non-Small Cell Lung Cancer (NSCLC) With Epidermal… · Janssen-Cilag Farmaceutica Ltda.
2026-08-26
critical
Primary completion pushed: 2026-06-26 → 2026-12-26
Completion pushed: 2026-06-26 → 2026-12-26
NCT06987890 Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing… · Brigham and Women's Hospital
2026-08-01
critical
Primary completion pushed: 2029-01-01 → 2030-12-31
Completion pushed: 2033-01-01 → 2036-12-31
NCT07135882 Primary Radiotherapy In MEtastatic Lung Cancer · Trans Tasman Radiation Oncology Group · Phase 3
2026-08-26
critical
Primary endpoint(s) modified
NCT07781852 Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and… · Lumina Pharmaceuticals Inc · Early Phase 1
2026-08-15
critical
Primary completion pushed: 2025-07-07 → 2026-06-30
Enrollment reduced: 20 → 5 participants
Trial completed
NCT05758116 Tislelizumab Consolidation Therapy After Radiotherapy or Sequential Chemoradiation in… · Peking University Cancer Hospital & Institute · Phase 2
2026-08-06
critical
Primary completion pushed: 2026-07 → 2027-07
Completion pushed: 2026-07 → 2027-07
NCT03999710 Determining Whether Durvalumab in Combination With Radiation Therapy Can Prevent the… · Memorial Sloan Kettering Cancer Center · Phase 2
2026-08-05
critical
Primary completion pushed: 2025-11-30 → 2027-12-31
Enrollment reduced: 84 → 69 participants
Enrollment closed, study ongoing
Completion pushed: 2027-12-31 → 2028-05-31
NCT06969027 JS207Combined With Chemotherapy in First-line Treatment of Advanced NSCLC · Shanghai Junshi Bioscience Co., Ltd. · Phase 2
2026-08-11
notable
Primary completion pushed: 2026-08-30 → 2027-01
Completion pushed: 2026-12-30 → 2027-07
NCT06567704 Cancer-related Fatigue During Maintenance Immunotherapy for Non-small Cell Lung Cancer… · Wake Forest University Health Sciences
2026-07-30
critical
Primary endpoint(s) modified
Completion pushed: 2026-12-31 → 2027-12-31
NCT05247684 AK112 Neoadjuvant/Adjuvant Treatment for Resectable NSCLC · Akeso · Phase 2
2026-08-06
critical
Primary endpoint(s) modified
Primary completion moved earlier: 2030-06-28 → 2027-01-31
Trial arms changed: 7 → 9
NCT05176483 Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in… · Exelixis · Phase 1

Active trials by phase

Early Phase 1
15
Phase 1
140
Phase 1/2
136
Phase 2
485
Phase 2/3
16
Phase 3
152
Phase 4
20
Not charted: 363 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 1,327

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07279935 Osimertinib Combined With Chemotherapy in Patients Who Had Distant Recurrence After… AstraZeneca Recruiting 2026-08-27
NCT07704658 Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors Rigel Pharmaceuticals Recruiting 2026-08-10
NCT07754812 Oral Paclitaxel Solution With Immunotherapy and Concurrent SBRT as Neoadjuvant Treatment… Shanghai Pulmonary Hospital, Shanghai, China Recruiting 2026-08-10
NCT07744698 Metronomic Oral Paclitaxel Plus PD-1/ PD-L1 Inhibitor Maintenance in Advanced Lung Cancer… Anhui Provincial Cancer Hospital Recruiting 2026-08-04
NCT07320105 Postoperative Radiotherapy for Postoperative N2 Metastases of NSCLC in the Immunotherapy… Fujian Cancer Hospital Recruiting 2026-01-06
NCT07092202 Firmonertinib Combined With Intrathecal Injection for the Treatment of EGFR Mutant NSCLC… Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Recruiting 2025-07-29
NCT06561620 Befotertinib Adjuvant Therapy in Stage IA2-IB NSCLC Patients Fudan University Recruiting 2024-08-22
NCT05172739 Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in… University of Crete Recruiting 2021-12-29
NCT05144997 Lorlatinib Continuation Study Pfizer Active, Not Recruiting 2026-08-26
NCT07671560 Efficacy and Safety of Ensartinib Combined With Anlotinib in Lorlatinib-Resistant… Qiming Wang Not Yet Recruiting 2026-06-26
NCT07633613 Pharmacokinetic Study of Pembrolizumab and Its Impact on Immunity and the Tumor… Centre Antoine Lacassagne Not Yet Recruiting 2026-06-08
NCT06282874 Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases Guangdong Association of Clinical Trials Active, Not Recruiting 2026-04-09
NCT05160922 Crizotinib Continuation Clinical Study Pfizer Active, Not Recruiting 2026-03-30
NCT07469488 A Clinical Trial on the Outcomes of Comprehensive Enhanced Prophylaxis Management (CEPM)… Shanghai Pulmonary Hospital, Shanghai, China Not Yet Recruiting 2026-03-13
NCT06893354 Explore the Mechanisms Underlying Disease Resistance and Potential Primary Resistance… The First Affiliated Hospital of Guangzhou Medical University Not Yet Recruiting 2025-03-25
NCT04413201 AFAMOSI: Efficacy and Safety of Afatinib Followed by Osimertinib Compared to Osimertinib… Michael Hopp Active, Not Recruiting 2025-03-25
NCT06785584 Efficacy and Safety of Ensartinib in Neoadjuvant Therapy for Stage IIA - IIIB (Operable… Fujian Medical University Union Hospital Not Yet Recruiting 2025-01-21
NCT06483009 Efficacy and Safety of Combination Therapy of Sintilimab and Chemotherapy With… Shanghai Chest Hospital Not Yet Recruiting 2024-08-30
NCT06356675 A Single-arm Pilot Study of Tislelizumab Combined With Anlotinib in Patients With… The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine Not Yet Recruiting 2024-04-10
NCT06276933 A Study of Camrelizumab Combined With Chemotherapy ± Thalidomide in First-line Treatment… Tongji University Not Yet Recruiting 2024-02-26
Phase 3
NCT06170788 Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab… Merck Sharp & Dohme LLC Recruiting 2026-08-27
NCT06881784 Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301) Revolution Medicines, Inc. Recruiting 2026-08-27
NCT05920356 A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum… Amgen Recruiting 2026-08-27
NCT07388524 Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early… National Cancer Institute (NCI) Recruiting 2026-08-25
NCT06765109 Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC Nuvalent Inc. Recruiting 2026-08-25

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