Disease landscape

ALS clinical trials

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306 active trials 191 recruiting 19 Phase 3 206 sponsors 39 changes in 30 days

Data updated daily from ClinicalTrials.gov, last refresh 2026-08-28

What changed in the last 30 days showing 38 of 39 changes on 20 trials

2026-07-30
Primary completion pushed: 2027-03 → 2028-06
Completion pushed: 2027-03 → 2028-06
NCT06704347 Safety Study of XT-150 in Participants With ALS · Xalud Therapeutics, Inc. · Phase 1
2026-08-22
Primary completion pushed: 2026-08-31 → 2028-12-31
Completion pushed: 2026-08-31 → 2030-12-31
NCT03567213 Investigation on the Cortical Communication (CortiCom) System · Johns Hopkins University
2026-08-18
Primary completion pushed: 2027-05-01 → 2027-08-01
Recruitment opened
Completion pushed: 2027-05-31 → 2027-10-31
NCT07224269 Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis · University of Iowa · Early Phase 1
2026-08-11
Primary completion pushed: 2027-12-31 → 2029-12-31
Completion pushed: 2027-12-31 → 2029-12-31
NCT06209515 Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease… · Kuopio University Hospital
2026-08-05
Primary completion pushed: 2026-06 → 2026-12
Completion pushed: 2026-06 → 2026-12
NCT06609213 Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and… · Andrea Charvet
2026-07-31
Primary completion pushed: 2028-03-31 → 2030-03-31
Enrollment increased: 15 → 25 participants
NCT07257302 Lung Insufflation Capacity Training and Respiratory Function in Amyotrophic Lateral… · National Center of Neurology and Psychiatry, Japan
2026-07-31
Primary completion pushed: 2026-06-30 → 2030-08-31
Primary endpoint(s) modified
Completion pushed: 2026-06-30 → 2030-08-31
NCT04363684 ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) · Mayo Clinic
2026-08-07
Phase changed: Phase 2 → Phase 2/3
NCT07161999 Study of COYA 302 for the Treatment of ALS · Coya Therapeutics · Phase 2/3
2026-08-25
Trial status changed: No Longer Available → Available
NCT05281484 Three Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01, CNMAu8.EAP02, and… · Clene Nanomedicine
2026-08-14
Enrollment closed, study ongoing
Primary completion moved earlier: 2027-12-16 → 2027-05-26
Completion moved earlier: 2027-12-16 → 2027-05-26
NCT07223723 A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese… · Biogen · Phase 4
2026-08-06
Recruitment opened
NCT07674667 FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS · Trace Neuroscience, Inc. · Phase 1/2
2026-08-09
Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University → Second Affiliated Hospital, Zhejiang University, School of Medicine
NCT07460037 Chinese-Specific Speech Imagery Coding Using High-Density ECoG · Second Affiliated Hospital, School of Medicine, Zhejiang University
2026-08-19
Trial status changed: Available → No Longer Available
NCT06743776 Scalable Expanded Access With Analysis of Neurofilament and Other Biomarkers for… · Mayo Clinic
2026-08-11
Recruitment opened
Primary completion pushed: 2030-06 → 2030-07-15
Completion pushed: 2030-06 → 2031-07-15
NCT07571486 Therapeutic Approach of Repeated Transient Blood-brain Barrier Opening in Amyotrophic… · Assistance Publique - Hôpitaux de Paris · Phase 1/2
2026-07-31
Trial completed
Primary completion pushed: 2026-03 → 2026-04-13
Completion pushed: 2026-04 → 2026-05-13
NCT07047209 Trial of Oral Digoxin in Individuals With Amyotrophic Lateral Sclerosis (ALS) · Massachusetts General Hospital · Phase 2
2026-08-13
Trial completed
Primary completion pushed: 2026-06-30 → 2026-07-30
Enrollment increased: 20 → 23 participants
Completion pushed: 2026-06-30 → 2026-07-30
NCT06119087 Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort… · University of Pennsylvania
2026-08-12
Enrollment closed, study ongoing
NCT06286917 Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory… · Tampere University
2026-07-30
Trial sites expanded: 47 → 56 locations
NCT07322003 Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS · Prilenia · Phase 3
2026-07-31
Trial sites expanded: 32 → 37 locations
NCT06578195 ASSESS ALL ALS Study · St. Joseph's Hospital and Medical Center, Phoenix
2026-08-21
Completion pushed: 2026-06-30 → 2027-08-31
NCT04220021 Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD · University of Florida · Phase 2

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-07-31 NCT07739134 Multimodal Tracking of Therapy Activity and Effort During Rehabilitation ETH Zurich new
2026-07-13 NCT07698496 Evaluation of the Feasibility and Efficacy of a Chronic Brain-computer Interface for… University Hospital, Grenoble new
2026-07-07 NCT07688239 The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and… Tiziana Life Sciences LTD new Phase 2
2026-07-02 NCT07680361 Study of Home Use of the Jaco Robotic Manipulation Device by Individuals With Tetraplegia Association APPROCHE new
2026-06-29 NCT07674667 FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS Trace Neuroscience, Inc. new Phase 1/2
2026-06-22 NCT07660614 A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis Leal Therapeutics, Inc new Phase 1/2
2026-06-18 NCT07656714 HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory… Hospital Universitario Virgen Macarena new
2026-06-16 NCT07650019 EDA-Based Adaptive Support in VR ALS Training Acibadem University new
2026-06-09 NCT07636538 Auto-calibrating System for Upper Limb Disability Assessment, Neurological and… University of Pavia new
2026-06-04 NCT07625605 The Meals Study for Amyotrophic Lateral Sclerosis and Parkinson's Disease The University of Tennessee, Knoxville new

Active trials by phase

Early Phase 1
11
Phase 1
28
Phase 1/2
24
Phase 2
23
Phase 2/3
12
Phase 3
7
Phase 4
2
Not charted: 199 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 306

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT05923905 Clinical Study to Evaluate the Efficacy and Safety of FB1006 in the Treatment of ALS… Peking University Third Hospital Recruiting 2023-11-22
NCT07223723 A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese… Biogen Active, Not Recruiting 2026-08-13
Phase 3
NCT07322003 Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS Prilenia Recruiting 2026-08-25
NCT03127267 Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients AB Science Recruiting 2025-09-12
NCT04768972 FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics… Ionis Pharmaceuticals, Inc. Active, Not Recruiting 2026-07-21
NCT04856982 A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a… Biogen Active, Not Recruiting 2026-03-30
NCT07174492 Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment… AB Science Not Yet Recruiting 2025-10-03
NCT06973629 Efficacy and Safety of MSC-NTF (NurOwn) in Participants With Early Symptomatic ALS and… Brainstorm-Cell Therapeutics Not Yet Recruiting 2025-05-22
NCT05021536 Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment Amylyx Pharmaceuticals Inc. Active, Not Recruiting 2024-08-14
Phase 2/3
NCT07161999 Study of COYA 302 for the Treatment of ALS Coya Therapeutics Recruiting 2026-08-06
NCT06719947 HD-tDCS in Amyotrophic Lateral Sclerosis: A Multicenter Randomized Controlled Trial Universidade Federal do Rio Grande do Norte Recruiting 2026-07-20
NCT04302870 Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial University of Edinburgh Recruiting 2026-03-04
NCT06126315 Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS Mario Negri Institute for Pharmacological Research Recruiting 2025-09-25
NCT04220190 RAPA-501 Therapy for ALS Rapa Therapeutics LLC Recruiting 2025-06-18
NCT04297683 HEALEY ALS Platform Trial - Master Protocol Merit E. Cudkowicz, MD Active, Not Recruiting 2026-07-21
NCT07410806 HEALEY ALS Platform Trial - Regimen I NUZ-001 Merit E. Cudkowicz, MD Active, Not Recruiting 2026-07-20
NCT04057898 Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6… MediciNova Active, Not Recruiting 2026-03-06
NCT07325591 Efficacy and Safety of Tazbentetol in ALS Participants Spinogenix Not Yet Recruiting 2026-03-02
NCT07321860 This Study Evaluates the Safety, Target Engagement, and Preliminary Efficacy of… Gipfel Life Sciences GmbH Not Yet Recruiting 2026-01-07
NCT07082192 A Study to Evaluate the Efficacy and Safety of Different Doses of CB03-154 in Adult… Shanghai Zhimeng Biopharma, Inc. Not Yet Recruiting 2025-07-24
NCT06391645 Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine… Beijing Tiantan Hospital Not Yet Recruiting 2024-04-30
Phase 2
NCT07023835 Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral… Zydus Therapeutics Inc. Recruiting 2026-07-28
NCT07142291 PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS PhenoNet, Inc. Recruiting 2026-07-23
NCT07071935 A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS) University of Pennsylvania Recruiting 2026-06-26
NCT07294144 Tofersen in Non-SOD1 ALS Washington University School of Medicine Recruiting 2026-06-25
See all 306 active ALS trials with filters →

Top sponsors by active trials in this area

University of Miami (7) · n-Lorem Foundation (6) · National Institute of Neurological Disorders and Stroke (NINDS) (6) · Neuralink Corp (6) · Nova Southeastern University (6) · Istituto Auxologico Italiano (5) · Peking University Third Hospital (5) · Assistance Publique - Hôpitaux de Paris (4) · Beijing Tiantan Hospital (4) · Haukeland University Hospital (4)

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