HFCWO Vest Plus Mechanical Cough Assist Versus Cough Assist Alone on Respiratory Infections in ALS: a Pilot Trial

This pilot randomised single-blind trial evaluated whether adding high-frequency chest wall oscillation (HFCWO) via chest vest (ComfortCough II) to mechanical cough assist improves respiratory outcomes and reduces respiratory infections and hospital admissions compared to mechanical cough assist alone in patients with amyotrophic lateral sclerosis (ALS) receiving non-invasive ventilation.

NCT Number	NCT07656714
Lead Sponsor	Hospital Universitario Virgen Macarena
Conditions	Amyotrophic Lateral Sclerosis, Respiratory Infection
Enrollment	14 participants
Start Date	2021-04-15
Primary Completion	2023-11-02 (estimated)
Study Completion	2025-04-27 (estimated)
Updated on ClinicalTrials.gov	2026-06-18