AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight

Study acronym: AMAZE 2
StatusRecruiting
PhasePhase 3
Started

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Record History

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  1. Lead sponsor: Novo Nordisk A/S to Novo Nordisk A/S
    • Eligibility criteria expanded, about 10 words
    • Secondary endpoints: details revised at 10 of 28 entries
    • Site details revised at 3 of 74 sites
  2. Study sites revised (74)v7
  3. Site details revised at 6 of 74 sitesv6
  4. Study sites revised (74)v5
  5. Site details revised at 5 of 74 sitesv4
  6. Primary completion pushed from May 15, 2028 to Aug 7, 2028
    • Study sites: 73 to 74
    v3
  7. Recruitment opened
    • Site details revised at 73 of 73 sites
    v2
  8. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Novo Nordisk
269 trials monitored
See 14 trials at risk
Diabetes
5,133 trials monitored
See 238 trials at risk
Obesity
3,903 trials monitored
See 160 trials at risk
The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight and type 2 diabetes. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Trial Details
NCT Number NCT07533175
Lead Sponsor Novo Nordisk A/S
Conditions
(from sponsor)		 Diabetes Mellitus, Overweight, Obesity
Related terms Diabetes Mellitus, Obesity, Overweight
Enrollment 630 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov