Disease landscape

Obesity clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-17

What changed in the last 30 days

267 trials changed in the last 30 days: 1 stopped, 100 with notable changes, 166 with minor changes only.

  1. Stopped

    Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance · Obesity or Overweight With Weight-Related Comorbidities

    Trial terminated

    Also in this update: Final enrollment: 8 participants — 7% of the 120 planned; Primary completion date changed from estimate of Nov 30, 2026 to Sep 11, 2026

    Verdiva Bio Dev LimitedPhase 2 NCT07553299 Registry history of NCT07553299 on ClinicalTrials.gov (opens the registry)

  2. Notable

    STEP-1 · RESET System Pivotal Clinical Trial (Protocol Revision K)

    Primary completion pushed from Mar 30, 2027 to Dec 30, 2027

    Also in this update: Trial sites expanded: 12 → 27 locations; Study completion pushed from May 1, 2027 to Sep 30, 2029; and 4 more changes in the last 30 days

    Morphic Medical Inc.Not applicable NCT04101669 Registry history of NCT04101669 on ClinicalTrials.gov (opens the registry)

  3. Notable

    GEM · Continuous Glucose and E-Monitoring to Support Healthy Weight Gain in Pregnancies - The GEM Study

    Primary completion pushed from Apr 30, 2026 to Jul 30, 2027

    Also in this update: Recruitment opened; Study completion pushed from Jul 30, 2026 to Sep 30, 2027

    Arkansas Children's Hospital Research InstituteNot applicable NCT06666257 Registry history of NCT06666257 on ClinicalTrials.gov (opens the registry)

Show 166 trials with minor changes only
  1. Minor

    SEMA-CKM · Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes

    Completed without a posted recruiting period

    Also in this update: Primary completion date changed from estimate of Apr 2026 to Sep 28, 2026; Final enrollment: 3392 participants (planned 400)

    LMC Diabetes & Endocrinology Ltd.Not specified NCT07424430 Registry history of NCT07424430 on ClinicalTrials.gov (opens the registry)

  2. Minor

    BaSES · How Does Bariatric Surgery Affect Social Experiences and Well-being - The BaSES-study

    Trial status changed: Enrolling by Invitation → Completed

    Also in this update: Study completion date changed from estimate of Jun 2026 to Nov 5, 2025; Final enrollment: 134 participants (planned 113)

    The Hospital of VestfoldNot applicable NCT05207917 Registry history of NCT05207917 on ClinicalTrials.gov (opens the registry)

  3. Minor

    ENDOCATA · Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion

    Trial completed

    Also in this update: Primary completion date changed from estimate of Sep 2027 to May 19, 2026; Final enrollment: 53 participants (planned 45)

    Centre Hospitalier Universitaire DijonNot applicable NCT04940962 Registry history of NCT04940962 on ClinicalTrials.gov (opens the registry)

  4. Minor
    29 trials marked Unknown by the registry's verification sweep
    1. Minor

      Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting

      Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.Phase 1 NCT06601517 Registry history of NCT06601517 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  5. Minor
    2 trials marked Unknown by the registry's verification sweep

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-15 NCT07875283 Analgesia After Endoscopic Sleeve Gastroplasty American Hospital of Paris new
2026-10-13 NCT07870668 Intermittent Phentermine for Obesity and Body Composition OSCAR MANUEL TORRES FALCON new Phase 4
2026-10-13 NCT07869758 Gastric On in Obesity Management: Evaluation of the Safety and Efficacy of the 6-Month… Rigicon, Inc. new
2026-10-09 NCT07868978 Radial Artery Dimensions and the Effect of Anaesthetic Induction in Morbid Obesity Hilal Subaşı Artıran new
2026-10-09 NCT07869277 Obesity and Clinical and Cytokine Responses to Periodontal Therapy Emine Çifcibaşı new
2026-10-08 NCT07866365 Longitudinal Tracking Study on the Path Evolution of College Students' Proactive Health… Yingying Tan new
2026-10-05 NCT07857018 Long-term Follow-up After Childhood Obesity Ulla Toft new
2026-10-05 NCT07858331 Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access Kristin Clemens new Phase 4
2026-09-30 NCT07850466 TRPTI Metabolic and GLP-1 Pharmacodynamic Study RDC Clinical Pty Ltd new Phase 4
2026-09-29 NCT07846865 Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep… Woolcock Institute of Medical Research new Phase 2/3

Active trials by phase

Early Phase 1
26
Phase 1
164
Phase 1/2
36
Phase 2
158
Phase 2/3
12
Phase 3
164
Phase 4
116
Not charted: 2,069 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 2,745

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT07657676 Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and… China National Center for Cardiovascular Diseases Recruiting 2026-10-13
NCT07870538 A Neuropsychobiological Approach to Optimize Patient Selection for GLP-1-based… Universitaire Ziekenhuizen KU Leuven Recruiting 2026-10-13
NCT07218445 The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in… Mayo Clinic Recruiting 2026-10-06
NCT05838287 Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants The University of Texas Health Science Center at San Antonio Recruiting 2026-09-22
NCT07777575 Resistance Training to Prevent Muscle Loss During Treatment With Tirzepatide Technical University of Munich Recruiting 2026-09-17
NCT07699445 The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With… Massachusetts General Hospital Recruiting 2026-09-11
NCT06132477 Impact GLP-1 Agonists Following Bariatric University of Missouri-Columbia Recruiting 2026-09-10
NCT07247084 A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants… Eli Lilly and Company Recruiting 2026-09-09
NCT06857942 A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation… Eli Lilly and Company Recruiting 2026-09-04
NCT05051436 The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics Philip Kern Recruiting 2026-08-31
NCT07154719 GLP-1R Actions on Muscle and the Skeleton Pennington Biomedical Research Center Recruiting 2026-08-27
NCT07554638 Incretin Therapies in Obesity-related HFpEF Columbia University Recruiting 2026-08-24
NCT07275697 Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study Emma Svennberg Recruiting 2026-08-10
NCT06374875 Fibrosis Lessens After Metabolic Surgery The Cleveland Clinic Recruiting 2026-07-31
NCT07728383 A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity Gila Therapeutics, Inc. Recruiting 2026-07-27
NCT07257484 Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors Weill Medical College of Cornell University Recruiting 2026-07-22
NCT06396416 Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2 Western University, Canada Recruiting 2026-06-29
NCT05919797 Weight Loss Study: Genetics and Response to Naltrexone/Bupropion Columbia University Recruiting 2026-06-10
NCT05320796 The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass Prof Urs Zingg Recruiting 2026-06-09
NCT05975580 Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain… University of California, Irvine Recruiting 2026-06-09
NCT07588438 Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay. Las Rías Medical Center Recruiting 2026-05-19
NCT06721507 2024 Tirzepatide-Bariatric Surgery Marlene Starr Recruiting 2026-05-14
NCT05305313 Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia… Sir Ganga Ram Hospital Recruiting 2026-04-27
NCT07096908 Tirzepatide Use in People With Obesity and Type 1 Diabetes Dasman Diabetes Institute Recruiting 2026-04-20
NCT07513168 Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults Asian Institute Of Medical Sciences Recruiting 2026-04-06

Top sponsors by active trials in this area

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