Also listed under Glucose Metabolism Disorders

ClinicalTrials.gov term: Diabetes Mellitus

Disease landscape

Diabetes clinical trials

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Data updated daily from ClinicalTrials.gov, last refresh 2026-10-17

What changed in the last 30 days

290 trials changed in the last 30 days: 6 stopped, 122 with notable changes, 162 with minor changes only.

  1. Stopped

    AFS_T1D · Artificial Sweetener (AFS) on Glucose Metabolism · Type 1 Diabetes (T1D)

    Trial terminated

    Also in this update: Primary completion date changed from estimate of Nov 1, 2025 to Sep 22, 2026; Final enrollment: 3 participants (planned 25)

    McGill University Health Centre/Research Institute of the McGill University Health CentreNot specified NCT06315725 Registry history of NCT06315725 on ClinicalTrials.gov (opens the registry)

  2. Notable

    STEP-1 · RESET System Pivotal Clinical Trial (Protocol Revision K)

    Primary completion pushed from Mar 30, 2027 to Dec 30, 2027

    Also in this update: Trial sites expanded: 12 → 27 locations; Study completion pushed from May 1, 2027 to Sep 30, 2029; and 4 more changes in the last 30 days

    Morphic Medical Inc.Not applicable NCT04101669 Registry history of NCT04101669 on ClinicalTrials.gov (opens the registry)

Show 162 trials with minor changes only
  1. Minor

    Preventing Medication Mismanagement · Dementia Through Automated Medication Dispensing With Facial Recognition and Video Observation

    Trial completed

    Also in this update: Primary completion date changed from estimate of May 31, 2026 to Sep 30, 2025; Final enrollment: 50 participants (planned 70)

    HiDO TechnologiesPhase 2 NCT06691256 Registry history of NCT06691256 on ClinicalTrials.gov (opens the registry)

  2. Minor

    enCompass · Expanding the Support of Family Caregivers of Diverse · Cancer and Diabetes

    Enrollment closed, study ongoing

    Also in this update: Study completion moved earlier from May 1, 2027 to Jan 27, 2027; Primary completion date changed from estimate of Nov 1, 2026 to Sep 16, 2026

    UNC Lineberger Comprehensive Cancer CenterNot applicable NCT07061652 Registry history of NCT07061652 on ClinicalTrials.gov (opens the registry)

  3. Minor

    SEMA-CKM · Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes

    Completed without a posted recruiting period

    Also in this update: Primary completion date changed from estimate of Apr 2026 to Sep 28, 2026; Final enrollment: 3392 participants (planned 400)

    LMC Diabetes & Endocrinology Ltd.Not specified NCT07424430 Registry history of NCT07424430 on ClinicalTrials.gov (opens the registry)

  4. Minor

    ATRACTion · Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool · Autoimmunity and Inflammation

    Trial completed

    Also in this update: Study completion date changed from estimate of Jun 2026 to Oct 21, 2025; Final enrollment: 325 participants (planned 500)

    Institut National de la Santé Et de la Recherche Médicale, FranceNot specified NCT04902807 Registry history of NCT04902807 on ClinicalTrials.gov (opens the registry)

  5. Minor

    ENDOCATA · Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion

    Trial completed

    Also in this update: Primary completion date changed from estimate of Sep 2027 to May 19, 2026; Final enrollment: 53 participants (planned 45)

    Centre Hospitalier Universitaire DijonNot applicable NCT04940962 Registry history of NCT04940962 on ClinicalTrials.gov (opens the registry)

  6. Minor
    44 trials marked Unknown by the registry's verification sweep
    1. Minor

      Proof of Concept (PoC), Randomized, Controlled Study to Validate the Algorithm and Evaluate the Accuracy, Safety and Pain Level of the Smartest-AE in Comparison to Self-measure Blood Glucose Levels

      Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Not Yet Recruiting

      Smartest TechnologiesNot applicable NCT06587087 Registry history of NCT06587087 on ClinicalTrials.gov (opens the registry)

      Changed

    Registry verification sweep

    Changed

  7. Minor
    2 trials marked Unknown by the registry's verification sweep

    Registry verification sweep

    Changed

  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.

New sponsor entrants, last 90 days sponsors with their first trial in this area

First postedTrialSponsorPhase
2026-10-16 NCT07877948 Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in… BREGO Life Sciences new
2026-10-16 NCT07879144 Digital Nudges to Improve Heart Health Actions After Community Screening in Malaysia… Cardiovascular Advancement and Research Excellence Institute new
2026-10-15 NCT07876401 Effects of Progressive Muscle Relaxation on Anxiety, Depression, and Quality of Life in… Gul Dural new
2026-10-15 NCT07876258 A Study in Type 2 Diabetes Patients Who Are Taking Moderate Dose Insulin, Looking at the… Aimi Fadilah Mohamad new Phase 3
2026-10-13 NCT07871370 Silymarin Effects on Fatty Liver in Type 2 Diabetics University of Mosul new
2026-10-08 NCT07864805 Electromagnetic Therapy, Peripheral Vascular Diseases, Diabetes Ashraf Abdelaal new
2026-10-07 NCT07864480 Continuous Delivery of Ranibizumab Via the Port Delivery System for Proliferative… Southeast Retina Center, Georgia new Phase 4
2026-10-06 NCT07861373 DiaBuddy: AI-Enabled Digital Self-Management for Youth With Type 1 Diabetes Dr. Juwayria Omar new
2026-09-30 NCT07849725 Adaptation, Implementation, and Validation of an Innovative eHealth System for the… Universidad Antonio Nariño new
2026-09-30 NCT07850531 Precision Nutrition for Obesity and Prediabetes Prevention in Under-supported Communities Prairie View A&M University new

Active trials by phase

Early Phase 1
52
Phase 1
126
Phase 1/2
58
Phase 2
207
Phase 2/3
28
Phase 3
167
Phase 4
194
Not charted: 2,851 active trials with no phase listed on ClinicalTrials.gov (typically behavioural, device, procedure and observational studies).

Active trials top 25 of 3,683

NCT IDTitleSponsorStatusUpdated
Phase 4
NCT06478186 Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II Diabetes University of Kansas Medical Center Recruiting 2026-10-13
NCT06445946 DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment… Ohio State University Recruiting 2026-10-07
NCT06706284 Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord… Marzieh Salehi Recruiting 2026-10-05
NCT07852988 Pancreatin Added to Standard Antihyperglycemic Therapy in Patients With Type 2 Diabetes Silesian Centre for Heart Diseases Recruiting 2026-10-01
NCT07843849 Corticosteroid for Diabetic Macular Edema (DME) Study Vanderbilt University Medical Center Recruiting 2026-09-28
NCT05838287 Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants The University of Texas Health Science Center at San Antonio Recruiting 2026-09-22
NCT06826339 Evaluating Several Cellular, Acellular, and Matrix-like Products (CAMPs) and Standard of… Tiger Biosciences, LLC. Recruiting 2026-09-22
NCT06642272 A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization… Herlev and Gentofte Hospital Recruiting 2026-09-18
NCT07494084 Sleep Loss and Circadian Misalignment - Mechanisms of Insulin Resistance Washington State University Recruiting 2026-09-18
NCT06054035 SGLT2 Inhibition in Addition to Lifestyle Intervention and Risk for Complications in… University Hospital Tuebingen Recruiting 2026-09-15
NCT03264352 Intervention for High-normal Blood Pressure in Adults With Type 2 Diabetes XueQing Yu Recruiting 2026-09-14
NCT05307731 Fingolimod for Type 2 Diabetes Mellitus General Hospital of Shenyang Military Region Recruiting 2026-09-10
NCT06132477 Impact GLP-1 Agonists Following Bariatric University of Missouri-Columbia Recruiting 2026-09-10
NCT07802561 Comparison of Metformin Versus Glyburide for Blood Sugar Control in Women With… Nishtar Medical University Recruiting 2026-09-03
NCT05051436 The Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics Philip Kern Recruiting 2026-08-31
NCT07771010 The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular… University Medical Centre Ljubljana Recruiting 2026-08-18
NCT05305287 Quantifying Hepatic Mitochondrial Fluxes in Humans The University of Texas Health Science Center at San Antonio Recruiting 2026-08-17
NCT07427251 The Postprandial Hypo-Avoid Study Steno Diabetes Center Copenhagen Recruiting 2026-08-13
NCT03883412 Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in… University of Virginia Recruiting 2026-08-12
NCT07112339 A Research Study to See How Well Weekly Insulin Icodec Maintains Blood Sugar Levels… Novo Nordisk A/S Recruiting 2026-08-11
NCT07228195 SGLT2i Therapy in Islet Transplantation (SIT) University of Minnesota Recruiting 2026-07-22
NCT07719894 Cilostazol and Aspirin for Cardiovascular Event Prevention in Patients With Type 2… Seoul National University Bundang Hospital Recruiting 2026-07-22
NCT07711171 Efficacy and Safety of Canagliflozin in the Treatment of Type 2 Diabetes With Mild… Fudan University Recruiting 2026-07-17
NCT05835037 Effect of Zinc on Glucose Homeostasis University of Maryland, Baltimore Recruiting 2026-07-10
NCT06003153 GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at… Massachusetts General Hospital Recruiting 2026-07-08

Top sponsors by active trials in this area

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