MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD)

StatusRecruiting
PhasePhase 1
Started

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Record History

  1. Study First Submitted
This is a single-center, open-label clinical study designed to evaluate alpha-synuclein (ASYN) deposition in the brain of participants with Parkinson's disease (PD), as compared with healthy elderly (HE) participants. Up to 18 participants (12 PD, 6 HE) are planned to be enrolled. Each participant will receive a single IV injection of \[¹⁸F\]MK-0947 as part of Part 1A followed by PET imaging using the Investigational United Imaging NeuroEXPLORER(NX) camera or the Siemens Biograph mCT camera. If enrolled in Part 1B a second injections and PET scan may be conducted in participants with PD and HE from Part 1A.
Trial Details
NCT Number NCT07880379
Lead Sponsor XingImaging, LLC
Conditions
(from sponsor)		 Parkinsons Disease (PD), Healthy Elderly Volunteers
Related terms Nerve Degeneration, Parkinson Disease, Parkinson Disease 4, Autosomal Dominant Lewy Body
Enrollment 18 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov