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Phenotypic and Functional Characterization of Bone Marrow Macrophages in Chronic Myelomonocytic Leukemia

Name: Phenotypic and Functional Characterization of Bone Marrow Macrophages in Chronic Myelomonocytic Leukemia — clinical trial record (NCT07852494)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Study acronym: MAC-AGE

StatusNot Yet Recruiting

PhaseNot applicable

SponsorCentre Hospitalier Universitaire de Nice

Started2026-11-01

View on ClinicalTrials.gov ↗

Centre Hospitalier Universitaire de Nice

356 trials monitored

See 12 trials at risk

Leukemia

2,553 trials monitored

See 134 trials at risk

MDS/MPN Overlap

180 trials monitored

See 13 trials at risk

MAC-AGE is a single-center study designed to characterize bone marrow macrophages in patients with chronic myelomonocytic leukemia (CMML) and to compare them with macrophages from age-matched controls undergoing elective total hip arthroplasty. Phenotypic, transcriptional and functional analyses will be performed using spectral/multiparametric flow cytometry, single-cell RNA sequencing and ex vivo functional assays. The study aims to identify CMML-associated macrophage alterations and potential therapeutic targets within the bone marrow immune microenvironment.

Trial Details

NCT Number	NCT07852494
Lead Sponsor	Centre Hospitalier Universitaire de Nice Collaborators: INSERM U1065 - Centre Méditerranéen de Médecine Moléculaire (C3M)
Conditions	Chronic Myelomonocytic Leukemia
Enrollment	120 participants
Start Date	2026-11-01
Primary Completion	2029-11-01 (estimated)
Study Completion	2030-01-01 (estimated)
Updated on ClinicalTrials.gov	2026-10-01