Effects of SPSIP Block on Perioperative Inflammation and TLR4 in Breast Cancer Surgery

Study acronym: SPSIP-TLR4
StatusRecruiting
PhaseNot applicable
Started

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Record History

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  1. Start date moved earlier from Jul 14, 2026 to Jun 22, 2026
  2. Study title revised
  3. Study First Submitted
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study will investigate whether the serratus posterior superior intercostal plane (SPSIP) block improves postoperative recovery after breast cancer surgery. Participants will be randomly assigned to one of two groups. One group will receive an ultrasound-guided SPSIP block, while the other group will undergo a similar procedure without active medication (sham procedure). Both groups will receive standard general anesthesia and postoperative pain management. Postoperative pain intensity, need for additional pain medication, nausea and vomiting, length of hospital stay, and persistent pain at 3 months after surgery will be assessed. Blood samples collected before surgery and at predetermined postoperative time points will be used to evaluate the body's inflammatory response to surgery and innate immune system activity. These assessments will include toll-like receptor 4 (TLR4), an immune-system marker, and selected inflammatory markers. The main question of this study is whether the SPSIP block, compared with the sham procedure, reduces the surgery-related inflammatory response and improves postoperative pain outcomes.
Trial Details
NCT Number NCT07843212
Lead Sponsor Mucahide Emine Fidancı Kuas
Conditions
(from sponsor)		 Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Breast Cancer, Toll-Like Receptors
Related terms Breast Neoplasms, Macular Degeneration, Age-Related, 10, Postoperative Pain
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov