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ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer

Name: ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer — clinical trial record (NCT07841236)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 2

SponsorFudan University

Started2026-09-14

View on ClinicalTrials.gov ↗

Fudan University

624 trials monitored

See 9 trials at risk

Colorectal Cancer

2,904 trials monitored

See 127 trials at risk

This prospective, multicenter, single-arm phase II interventional study evaluates whether longitudinal circulating tumor DNA (ctDNA) monitoring can guide neoadjuvant immunotherapy and surgical decision-making in dMMR/MSI-H colon cancer. Participants with ctDNA clearance proceed to curative surgery, whereas those with persistent ctDNA positivity escalate to combined PD-1 and CTLA-4 inhibitor therapy.

Trial Details

NCT Number	NCT07841236
Lead Sponsor	Fudan University
Conditions	Colon Cancer, Deficient Mismatch Repair, Microsatellite Instability-High (MSI-H)
Enrollment	23 participants
Start Date	2026-09-14
Primary Completion	2027-12-31 (estimated)
Study Completion	2030-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-09-25