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Prophylactic Nanocrystalline Megestrol Acetate Versus Placebo for Chemoradiotherapy-Related Anorexia in Nasopharyngeal Carcinoma

Name: Prophylactic Nanocrystalline Megestrol Acetate Versus Placebo for Chemoradiotherapy-Related Anorexia in Nasopharyngeal Carcinoma — clinical trial record (NCT07796789)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

StatusRecruiting

PhasePhase 3

SponsorSun Yat-sen University

Started2026-08-30

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Sun Yat-sen University

609 trials monitored

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Head & Neck Cancer

2,051 trials monitored

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This phase III randomized, double-blind, placebo-controlled trial evaluates whether nanocrystalline megestrol acetate can reduce anorexia in patients with locally advanced nasopharyngeal carcinoma (NPC) undergoing concurrent chemoradiotherapy (CCRT). The study aims to confirm the clinical benefits of adding this agent to standard CCRT for improving appetite, quality of life, nutritional status, and survival outcomes.

Trial Details

NCT Number	NCT07796789
Lead Sponsor	Sun Yat-sen University
Conditions	Nasopharyngeal Cancinoma (NPC)
Enrollment	204 participants
Start Date	2026-08-30
Primary Completion	2027-08-30 (estimated)
Study Completion	2029-08-30 (estimated)
Updated on ClinicalTrials.gov	2026-09-01